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Early-life estrogens and prostate cancer in an animal model

Published online by Cambridge University Press:  09 November 2010

G. S. Prins  and
S.-M. Ho
G. S. Prins*
Affiliation:
Departments of Urology and Physiology, University of Illinois at Chicago, Illinois, USA
S.-M. Ho
Affiliation:
Department of Environmental Health, University of Cincinnati, Ohio, USA
*
*Address for correspondence: G. S. Prins, PhD, Department of Urology, University of Illinois at Chicago, 820 S Wood St, MC955, Chicago, IL 60612, USA. (Email gprins@uic.edu)
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Abstract

While early-life estrogens are thought to play a physiologic role in prostate gland development, inappropriate estrogenic exposures either in dose, type or temporally can reprogram the prostate gland and increase susceptibility to abnormal prostate growth with aging including carcinogenesis. This review discusses the evidence for developmental estrogenic reprogramming that leads to adult prostate disease in a rat model. We propose that estrogen imprinting of the prostate is mediated through both structural reorganization of the gland early in life and epigenomic reprogramming that permits life-long memory of the inappropriate developmental exposures including heightened sensitivity to rising estradiol levels with aging. Complex interactions between early epigenetic programming and later-life experiences results in an emergence of multiple epigenomic outcomes, with some contributing to carcinogenesis with aging.

Keywords

bisphenol Aestrogenestrogenizationprostate developmentreprogramming
Type
Reviews
Information
Journal of Developmental Origins of Health and Disease , Volume 1 , Issue 6 , December 2010 , pp. 365 - 370
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2010

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