MRS Proceedings

Table of Contents - Volume  1272  - Symposia KK/LL/NN/OO/PP – Integrated Miniaturized Materials-From Self-Assembly to Device Integration  

Editors : C.J. Martinez, J. Cabral, A. Fernandez-Nieves, S. Grego, A. Goyal, Q. Lin, J.J. Urban, J.J. Watkins, A. Saiani, R. Callens, J.H. Collier et al


Fabrication and Applications of Three Dimensional Porous Microwells

2010 MRS Spring Meeting.

Christina L Randalla1, Yevgeniy V Kalinina2, Anum Azama3 and David Graciasa4

a1, Johns Hopkins University, Baltimore, Maryland, United States

a2, Johns Hopkins University, Baltimore, Maryland, United States

a3, Johns Hopkins University, Baltimore, Maryland, United States

a4, Johns Hopkins University, Chemical and Biomolecular Engineering, 3400 N Charles Street, 125 Maryland Hall, Baltimore, Maryland, 21218, United States, 410-516-5284, 410-516-5510


In many biological applications, such as cell therapy and drug delivery, there is a need to enhance diffusion by enabling chemical transport in all three dimensions. We highlight this need by comparing diffusion in a conventional two-dimensional (2D) microwell with diffusion in a three-dimensional (3D) cubic microwell using numerical simulations. We also describe the fabrication of hollow polymeric (and biocompatible) cubic microwells and microwell arrays. We emphasize that since the assembly process is compatible with 2D lithographic patterning, porosity can be precisely patterned in all three dimensions. Hence, this platform provides considerable versatility for a variety of applications.

(Received April 21 2010)

(Accepted September 15 2010)

Key Words:

  • microelectro-mechanical (MEMS);
  • biomedical;
  • self-assembly