a1 Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, U.K.
Background: The orbitofrontal cortex has been implicated as a key component in depression by several imaging studies. This study aims to examine morphometrically glial cell and neuronal density and neuronal volume in the orbitofrontal cortex of late-life major depression patients.
Methods: Post mortem tissue from 13 patients with major depression and 11 matched controls was obtained and analyzed using the optical disector and nucleator methods.
Results: No changes were found in glial cell, pyramidal or non-pyramidal neuron density, or in non-pyramidal and pyramidal neuron volume in the orbitofrontal cortex.
Conclusions: Based on previous findings, this study suggests variability in morphological changes within the orbitofrontal cortex, as well as the prefrontal cortex as a whole.
(Received January 14 2010)
(Revised March 18 2010)
(Accepted March 28 2010)
(Online publication June 18 2010)
c1 Correspondence should be addressed to: Ahmad Khundakar, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, U.K. Phone: +44 (0)191 445 5212; Fax: +44 (0)191 445 6685. Email: firstname.lastname@example.org.