Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-23T09:05:25.185Z Has data issue: false hasContentIssue false
  • English
  • Français

Magnetic Nanoparticles for Early Detection of Cancer by Magnetic Resonance Imaging

Published online by Cambridge University Press:  31 January 2011

Wenbin Lin ,
Taeghwan Hyeon ,
Gregory M. Lanza ,
Miqin Zhang  and
Thomas J. Meade
Get access

Abstract

This article provides a brief overview of recent progress in the synthesis and functionalization of magnetic nanoparticles and their applications in the early detection of malignant tumors by magnetic resonance imaging (MRI). The intrinsic low sensitivity of MRI necessitates the use of large quantities of exogenous contrast agents in many imaging studies. Magnetic nanoparticles have recently emerged as highly efficient MRI contrast agents because these nanometer-scale materials can carry high payloads while maintaining the ability to move through physiological systems. Superparamagnetic ferrite nanoparticles (such as iron oxide) provide excellent negative contrast enhancement. Recent refinement of synthetic methodologies has led to ferrite nanoparticles with narrow size distributions and high crystallinity. Target-specific tumor imaging becomes possible through functionalization of ferrite nanoparticles with targeting agents to allow for site-specific accumulation. Nanoparticulate contrast agents capable of positive contrast enhancement have recently been developed in order to overcome the drawbacks of negative contrast enhancement afforded by ferrite nanoparticles. These newly developed magnetic nanoparticles have the potential to enable physicians to diagnose cancer at the earliest stage possible and thus can have an enormous impact on more effective cancer treatment.

Type
Research Article
Information
MRS Bulletin , Volume 34 , Issue 6: Nanofunctional Materials in Cancer Research , June 2009 , pp. 441 - 448
Copyright
Copyright © Materials Research Society 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Stark, D.D., Bradley, W.G. Jr., Magnetic Resonance Imaging (Mosby, St. Louis, 1999).Google Scholar
2Aime, S., Botta, M., Fasano, M., Terreno, E., Chem. Soc. Rev. 27, 19 (1998).CrossRefGoogle Scholar
3Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Chem. Rev. 99, 2293 (1999).CrossRefGoogle Scholar
4Larson, S.M., Cancer 67, (Suppl. 4), 1253 (1991).3.0.CO;2-J>CrossRefGoogle Scholar
5Yang, D.J., Kim, E.E., Inoue, T., Ann. Nucl. Med. 20, 1 (2006).CrossRefGoogle Scholar
6Gupta, H., Weissleder, R., Magn. Reson. Imaging Clin. N. Am. 4, 171 (1996).CrossRefGoogle Scholar
7Petersein, J., Saini, S., Weissleder, R., Magn. Reson. Imaging Clin. N. Am. 4, 53 (1996).CrossRefGoogle Scholar
8Corot, C., Robert, P., Idee, J.M., Port, M., Adv. Drug Deliv. Rev. 58, 1471 (2006).CrossRefGoogle Scholar
9Mendonca Dias, M.H., Lauterbur, P.C., Magn. Reson. Med. 3, 328 (1986).Google Scholar
10Semelka, R.C., Helmberger, T.K., Radiology 218, 27 (2001).CrossRefGoogle Scholar
11Kang, H.W., Josephson, L., Petrovsky, A., Weissleder, R., Bogdanov, A., Jr., Bioconjug. Chem. 13, 122 (2002).Google Scholar
12Harisinghani, M.G., Barentsz, J., Hahn, P.F., Deserno, W.M., Tabatabaei, S., van de Kaa, C.H., de la Rosette, J., Weissleder, R., N. Engl. J. Med. 348, 2491 (2003).CrossRefGoogle Scholar
13Harisinghani, M.G., Jhaveri, K.S., Weissleder, R., Schima, W., Saini, S., Hahn, P.F., Mueller, P.R., Clin. Radiol. 56, 714 (2001).Google Scholar
14Harisinghani, M.G., Saini, S., Weissleder, R., Halpern, E.F., Schima, W., Rubin, D.L., Stillman, A.E., Sica, G.T., Small, W.C., Hahn, P.F., Radiology 202, 687 (1997).CrossRefGoogle Scholar
15Weissleder, R., Elizondo, G., Stark, D.D., Hahn, P.F., Marfil, J., Gonzalez, J.F., Saini, S., Todd, L.E., Ferrucci, J.T., Am. J. Roentgenol. 152, 175 (1989).CrossRefGoogle Scholar
16Montet, X., Weissleder, R., Josephson, L., Bioconjug. Chem. 17, 905 (2006).CrossRefGoogle Scholar
17Kelly, K.A., Allport, J.R., Tsourkas, A., Shinde-Patil, V.R., Josephson, L., Weissleder, R., Circ. Res. 96, 327 (2005).CrossRefGoogle Scholar
18Schellenberger, E.A., Hogemann, D., Josephson, L., Weissleder, R., Acad. Radiol. 9 (Suppl. 2), S310 (2002).CrossRefGoogle Scholar
19Koenig, S.H., Keller, K.E., Magn. Reson. Med. 34, 227 (1995).Google Scholar
20Morales, M.P., Veintemillas-Verdaguer, S., Montero, M.I., Serna, C.J., Chem. Mater. 11, 3058 (1999).Google Scholar
21 (a)Jeong, U., Teng, X., Wang, Y., Yang, H., Xia, Y., Adv. Mater. 19, 33 (2007).CrossRefGoogle Scholar
(b)Cheon, J., Lee, J.H., Acc. Chem. Res. 41, 1630 (2008).CrossRefGoogle Scholar
(c)Aslam, M., Schultz, E.A., Sun, T., Meade, T.J., Dravid, V.P., Cryst. Growth Design 7, 471 (2007).CrossRefGoogle Scholar
22Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., Hyeon, T., Nat. Mater. 3, 891 (2004).CrossRefGoogle Scholar
23Jun, Y.-W., Huh, Y.-M., Choi, J.-S., Lee, J.-H., Song, H.-T., Kim, S., Yoon, S., Kim, K.-S., Shin, J.-S., Suh, J.-S., Cheon, J., J. Am. Chem. Soc. 127, 5732 (2005).CrossRefGoogle Scholar
24Lee, J.-H., Huh, Y.-M., Jun, Y.-W., Seo, J.-W., Jang, J.-T., Song, H.-T., Kim, S., Cho, E.-J., Yoon, H.-G., Suh, J.-S., Cheon, J., Nat. Med. 13, 95 (2007).CrossRefGoogle Scholar
25Xu, C., Xu, K., Gu, H., Zheng, R., Liu, H., Zhang, X., Guo, Z., Xu, B., J. Am. Chem. Soc. 126, 9938 (2004).CrossRefGoogle Scholar
26Kim, J.S., Valencia, C.A., Liu, R., Lin, W., Bioconjug. Chem. 18, 333 (2007).Google Scholar
27Kim, M., Chen, Y., Liu, Y., Peng, X., Adv. Mater. 17, 1429 (2005).CrossRefGoogle Scholar
28Kohler, N., Fryxell, G.E., Zhang, M., J. Am. Chem. Soc. 126, 7206 (2004).CrossRefGoogle Scholar
29Kim, J., Kim, H.S., Lee, N., Kim, T., Kim, H., Yu, T., Song, I.C., Moon, W.K., Hyeon, T., Angew. Chem. Int. Ed. 47, 8438 (2008).Google Scholar
30Bulte, J.W.M., Kraitchman, D.L., NMR Biomed. 17, 484 (2004).CrossRefGoogle Scholar
31Lanza, G.M., Winter, P.M., Caruthers, S.D., Hughes, M.S., Cyrus, T., Marsh, J.N., Neubauer, A.M., Partlow, K.C., Wickline, S.A., Nanomed 1 (3), 321 (2006).CrossRefGoogle Scholar
32Morawski, A.W., Winter, P.M., Crowder, K.C., Caruthers, S.D., Fuhrhop, R.W., Scott, M.J., Robertson, J.D., Abendschein, D.R., Lanza, G.M., Wickline, S.A., Magn. Reson. Med. 51, 480 (2004).CrossRefGoogle Scholar
33Caruthers, S.D., Wickline, S.A., Lanza, G.M., Curr. Opin. Biotechnol. 18, 26 (2007).CrossRefGoogle Scholar
34Winter, P.M., Caruthers, S.D., Kassner, A., Harris, T.D., Chinen, L.K., Allen, J.S., Lacy, E.K., Zhang, H., Robertson, J.D., Wickline, S.A., Lanza, G.M., Cancer Res. 63, 5838 (2003).Google Scholar
35Winter, P.M., Morawski, A.M., Caruthers, S.D., Fuhrhop, R.W., Zhang, H., Williams, T.A., Allen, J.S., Lacy, E.K., Robertson, J.D., Lanza, G.M., Wickline, S.A., Circulation 108, 2270 (2003).Google Scholar
36Lanza, G.M., Abendschein, D.R., Hall, C.S., Marsh, J.N., Scott, M.J., Scherrer, D.E., Wickline, S.A., Invest. Radiol. 35, 227 (2000).Google Scholar
37Zhu, D., White, R.D., Hardy, P.A., Weerapreeyakul, N., Sutthanut, K., Jay, M., J Nanosci. Nanotechnol. 6, 996 (2006).CrossRefGoogle Scholar
38Zhu, D., Lu, X., Hardy, P.A., Leggas, M., Jay, M., Invest. Radiol. 43, 129 (2008).CrossRefGoogle Scholar
39Kabalka, G., Buonocore, E., Hubner, K., Moss, T., Norley, N., Huang, L., Radiology 163, 255 (1987).CrossRefGoogle Scholar
(b)Kabalka, G.W., Buonocore, E., Hubner, K., Davis, M., Huang, L., Magn. Reson. Med. 8, 89 (1988).CrossRefGoogle Scholar
(c)Kabalka, G.W., Davis, M.A., Moss, T.H., Buonocore, E., Hubner, K., Holmberg, E., Maruyama, K., Huang, L., Magn. Reson. Med. 19, 406 (1991).CrossRefGoogle Scholar
40 (a)Unger, E.C., MacDougall, P., Cullis, P., Tilcock, C., Magn. Reson. Imaging 7, 417 (1989).Google Scholar
(b)Unger, E.C., Winokur, T., MacDougall, P., Rosenblum, J., Clair, M., Gatenby, R., Tilcock, C., Radiology 171 (1), 81 (1989).Google Scholar
(c)Sipkins, D.A., Cheresh, D.A., Kazemi, M.R., Nevin, L.M., Bednarski, M.D., Li, K.C., Nat. Med. 4, 623 (1998).Google Scholar
41Kamaly, N., Kalber, T., Ahmad, A., Oliver, M.H., So, P.W., Herlihy, A.H., Bell, J.D., Jorgensen, M.R., Miller, A.D., Bioconjug. Chem. 19, 118 (2008).CrossRefGoogle Scholar
42Bridot, J.-L., Faure, A.-C., Laurent, S., Rivière, C., Billotey, C., Hiba, B., Janier, M., Josserand, V., Coll, J.-L., Elst, L.V., Muller, R., Roux, S., Perriat, P., Tillement, O., J. Am. Chem. Soc. 129, 5076 (2007).CrossRefGoogle Scholar
43Evanics, F., Diamente, P.R., van Veggel, F.C.J.M., Stanisz, G.J., Prosser, R.S., Chem. Mater. 18, 2499 (2006).CrossRefGoogle Scholar
44Hifumi, H., Yamaoka, S., Tanimoto, A., Citterio, D., Suzuki, K., J. Am. Chem. Soc. 128, 15090 (2006).Google Scholar
45Gilad, A.A., Walczak, P., McMahon, M.T., Na, H.B., Lee, J.H., An, K., Hyeon, T., van Zijl, P.C.M., Bulte, J.W.M., Magn. Reson. Med. 60, 1 (2008).CrossRefGoogle Scholar
46Na, H.B., Lee, J.H., An, K., Park, Y.I., Park, M., Lee, I.S., Nam, D.-H., Kim, S.T., Kim, S.-H., Kim, S.-W., Lim, K.-H., Kim, K.-Soo, Kim, S.-O., Hyeon, T., Angew. Chem. Int. Ed. 46, 5397 (2007).Google Scholar
47Seo, W.S., Lee, J.H., Sun, X., Suzuki, Y., Mann, D., Liu, Z., Terashima, M., Yang, P.C., McConnell, M.V., Nishimura, D.G., Dai, H., Nat. Mater. 5, 971 (2006).Google Scholar
48Rieter, W.J., Kim, J.S., Taylor, K.M.L., An, H., Lin, W., Tarrant, T., Lin, W., Angew. Chem. Int. Ed. Engl. 46, 3680 (2007).CrossRefGoogle Scholar
49Kim, J.S., Rieter, W.J., Taylor, K.M.L., An, H., Lin, W., Lin, W., J. Am. Chem. Soc. 129, 8962 (2007).CrossRefGoogle Scholar
50Folkman, J., Nature Med. 1, 27 (1995).CrossRefGoogle Scholar
51Taylor, K.M.L., Kim, J.S., Rieter, W.J., An, H., Lin, W., Lin, W., J. Am. Chem. Soc. 130, 2154 (2008).CrossRefGoogle Scholar
52Rieter, W.J., Taylor, K.M.L., An, H., Lin, W., Lin, W., J. Am. Chem. Soc. 128, 9024 (2006).Google Scholar
53Rieter, W.J., Taylor, K.M.L., Lin, W., J. Am. Chem. Soc. 129, 9852 (2007).Google Scholar
54Taylor, K.M.L., Rieter, W.J., Lin, W., J. Am. Chem. Soc. 130, 14358 (2008).CrossRefGoogle Scholar