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A Multiscale Approach to Assess the Complex Surface of Polyurethane Catheters and the Effects of a New Plasma Decontamination Treatment on the Surface Properties

Published online by Cambridge University Press:  05 October 2010

Omar Mrad ,
Johanna Saunier ,
Caroline Aymes-Chodur ,
Véronique Rosilio ,
Sylvie Bouttier ,
Florence Agnely ,
Pascal Aubert ,
Jacky Vigneron ,
Arnaud Etcheberry  and
Najet Yagoubi
Omar Mrad
Affiliation:
Université Paris-Sud 11, EA 401, IFR 141, Faculté de Pharmacie, F-92296 Châtenay Malabry, France
Johanna Saunier*
Affiliation:
Université Paris-Sud 11, EA 401, IFR 141, Faculté de Pharmacie, F-92296 Châtenay Malabry, France
Caroline Aymes-Chodur
Affiliation:
Université Paris-Sud 11, EA 401, IFR 141, Faculté de Pharmacie, F-92296 Châtenay Malabry, France
Véronique Rosilio
Affiliation:
Université Paris-Sud 11, UMR 8612, Faculté de Pharmacie, F-92296 Châtenay Malabry, France CNRS, UMR 8612, Faculté de Pharmacie, F-92296 Châtenay Malabry, France
Sylvie Bouttier
Affiliation:
Université Paris-Sud 11, EA 3534, Faculté de Pharmacie, F-92296 Châtenay Malabry, France
Florence Agnely
Affiliation:
Université Paris-Sud 11, UMR 8612, Faculté de Pharmacie, F-92296 Châtenay Malabry, France CNRS, UMR 8612, Faculté de Pharmacie, F-92296 Châtenay Malabry, France
Pascal Aubert
Affiliation:
Université Evry Val d'Essonne, LMN, F-91000 Evry, France
Jacky Vigneron
Affiliation:
Université Versailles, ILV CNRS UMR 8180, Institut Lavoisier de Versailles, F-78035 Versailles, France
Arnaud Etcheberry
Affiliation:
Université Versailles, ILV CNRS UMR 8180, Institut Lavoisier de Versailles, F-78035 Versailles, France
Najet Yagoubi
Affiliation:
Université Paris-Sud 11, EA 401, IFR 141, Faculté de Pharmacie, F-92296 Châtenay Malabry, France
*
Corresponding author. E-mail: johanna.saunier@u-psud.fr
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Abstract

Polyurethane catheters made of Pellethane 2363-80AE® were treated with a low temperature plasma developed for the decontamination of reusable polymer devices in hospitals. We investigated the modifications of the polymer surface by studying the topographic modifications, the chemical modifications, and their consequences on the wettability and bacterial adhesion. This study showed that plasma treatment modified the topography and grafted oxygen and nitrogen species onto the surface, resulting in an increase in the surface polarity. This effect could be correlated to the number of nitrogen atoms interacting with the surface. Moreover, this study demonstrated the significance of multiscale heterogeneities, and the complexity of industrial medical devices made from polymers. Their surface can be heterogeneous, and they contain additives that can migrate and change the surface composition.

Keywords

polyurethaneplasma treatmentbloomingcontact angle measurementXPSAFMSEMbacterial adhesionadditives
Type
Atomic Force Microscopy Biological Applications
Information
Microscopy and Microanalysis , Volume 16 , Issue 6 , December 2010 , pp. 764 - 778
Copyright
Copyright © Microscopy Society of America 2010

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