The Journal of Laryngology & Otology

Clinical Records

Primary small cell carcinoma of lacrimal sac: case report and literature review

T Gotoa1a3, N Bandoha1a3 c1, T Nagatoa1, M Takaharaa1, Y Harabuchia1, Y Tokusashia2 and N Miyokawaa2

a1 Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Obihiro, Japan

a2 Department of Surgical Pathology, Asahikawa Medical College, Obihiro, Japan

a3 Head and Neck Cancer Center, Hokuto Hospital, Obihiro, Japan

Abstract

Objective: We present the first reported case of primary small cell carcinoma of the lacrimal sac.

Case report: A 67-year-old Japanese woman was referred to our department with a two-month history of left medial canthal swelling, epiphora and occasional nasal bleeding. Nasal endoscopy revealed a readily bleeding tumour in the left inferior meatus. Computed tomography and magnetic resonance imaging scans demonstrated that the tumour was mainly located in the left lacrimal sac. Histopathological studies of a biopsy specimen revealed small cell carcinoma. The patient was treated with four cycles of chemotherapy consisting of cisplatin and etoposide, in combination with radiotherapy. There was no evidence of recurrence or metastasis for five years.

Conclusion: Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and to have a poor prognosis. We report a case of primary small cell carcinoma of the lacrimal sac successfully treated with chemo-radiotherapy.

(Accepted February 02 2010)

(Online publication April 23 2010)

Correspondence:

c1 Address for correspondence: Dr Nobuyuki Bandoh, Head and Neck Cancer Center, Hokuto Hospital, Inadacho Kisen 7-5, Obihiro, Hokkaido, 080-0833, Japan. Fax: +81 155 47 3094 E-mail: bando@hokuto7.or.jp

Footnotes

Dr N Bandoh takes responsibility for the integrity of the content of the paper.

Competing interests: None declared