British Journal of Nutrition

Full Papers

Human and Clinical Nutrition

The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms

Ales Vidlara1, Jitka Vostalovaa2 c1, Jitka Ulrichovaa2, Vladimir Studenta1, David Stejskala3, Richard Reichenbacha4, Jana Vrbkovaa5, Filip Ruzickaa6 and Vilim Simaneka1

a1 Department of Urology, University Hospital, Olomouc, Czech Republic

a2 Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

a3 Department of Laboratory Medicine, Central Moravian Hospital, Prostejov Hospital, Prostejov, Czech Republic

a4 WALMARK a.s., Trinec-Oldrichovice, Czech Republic

a5 Department of Mathematical Analysis and Applications of Mathematics, Faculty of Science, Palacky University, Olomouc, Czech Republic

a6 Department of Microbiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Abstract

Lower urinary tract symptoms (LUTS) are a common condition in older men. The objective of the present study was to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with LUTS, elevated prostate-specific antigen (PSA), negative prostate biopsy and clinically confirmed chronic non-bacterial prostatitis. Forty-two participants received either 1500 mg of the dried powdered cranberries per d for 6 months (cranberry group; n 21) or no cranberry treatment (control group; n 21). Physical examination, International Prostate Symptom Score, quality of life (QoL), five-item version of the International Index of Erectile Function (IIEF-5), basic clinical chemistry parameters, haematology, Se, testosterone, PSA (free and total), C-reactive protein (CRP), antioxidant status, transrectal ultrasound prostate volume, urinary flow rate, ultrasound-estimated post-void residual urine volume at baseline, and at 3 and 6 months, and urine ex vivo anti-adherence activity were determined in all subjects. In contrast to the control group, patients in the cranberry group had statistically significant improvement in International Prostate Symptom Score, QoL, urination parameters including voiding parameters (rate of urine flow, average flow, total volume and post-void residual urine volume), and lower total PSA level on day 180 of the study. There was no influence on blood testosterone or serum CRP levels. There was no statistically significant improvement in the control group. The results of the present trial are the first firm evidence that cranberries may ameliorate LUTS, independent of benign prostatic hyperplasia or C-reactive protein level.

(Received February 15 2010)

(Revised April 13 2010)

(Accepted April 19 2010)

(Online publication August 31 2010)

Correspondence:

c1 Corresponding author: Dr Jitka Vostalova, fax +420 585 632 302, email psotova@tunw.upol.cz

Footnotes

Abbreviations: BHP, benign prostatic hyperplasia; CFP, cranberry fruit powder; CP, chronic prostatitis; CRP, C-reactive protein; IIEF-5, five-item version of the International Index of Erectile Function; IPSS, International Prostate Symptom Score; LUTS, lower urinary tract symptoms; PSA, prostate-specific antigen; PSAfree, free prostate-specific antigen; PSAtot, total prostate-specific antigen; Qmax, maximal urinary flow rate; QoL, quality of life