Hostname: page-component-7c8c6479df-xxrs7 Total loading time: 0 Render date: 2024-03-28T21:08:54.071Z Has data issue: false hasContentIssue false

Markers of bone turnover in relation to bone health

Published online by Cambridge University Press:  28 February 2007

Simon P. Robins
Affiliation:
Skeletal Research Unit, Rowett Research Institute, Aberdeen AB21 9SB
Susan A. New
Affiliation:
Centre for Nutrition & Food Safety, School of Biological Sciences, University of Surrey, Guildford GU2 5XH
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Symposium on ‘Nutritional aspects of bone’
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Abbiati, G., Bartucci, F., Longoni, A., Fincato, G., Galimberti, S., Rigoldi, M. & Castiglioni, C. (1993). Monitoring of free and total urinary pyridinoline and deoxypyridinoline in healthy volunteers: sample relationships between 24-h and fasting early morning urine concentrations. Bone and Mineral 21, 919.CrossRefGoogle ScholarPubMed
Alvarez, L., Guanabens, N., Peris, P., Monegal, A., Bedini, J., Deulofeu, R., Martinez de Osaba, J. M., Munoz, G.-J., Rivera-Fillat, F. & Ballesta, A. M. (1995). Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease. Journal of Bone and Mineral Research 10, 458465.Google Scholar
Arnett, T. R. & Dempster, D. W. (1986). Effect of pH on bone resorption by rat osteoclasts in vitro. Endocrinology 119, 119124.Google Scholar
Barger-Lux, M. J. & Heaney, R. P. (1993). Effects of calcium restriction on metabolic characteristics of premenopausal women. Journal of Clinical Endocrinology and Metabolism 76, 103107.Google ScholarPubMed
Bettica, P., Moro, L., Robins, S. P., Taylor, A. K., Talbot, J., Singer, F. R. & Baylink, D. J. (1992). The comparative performance of urinary bone resorption markers: galactosyl hydroxylysine, pyridinium crosslinks, hydroxyproline. Clinical Chemistry 38, 23132318.CrossRefGoogle Scholar
Bienkowski, R. (1984). Intracellular degradation of newly synthesized collagen. Collagen and Related Research 4, 399412.Google Scholar
Black, D., Duncan, A. & Robins, S. P. (1988). Quantitative analysis of the pyridinium crosslinks of collagen in urine using ion-paired reversed-phase high-performance liquid chromatography. Analytical Biochemistry 169, 197203.CrossRefGoogle ScholarPubMed
Bonde, M., Qvist, P., Fledelius, C., Riis, B. & Christiansen, C. (1994). Immunoassay for quantifying type I degradation products in urine evaluated. Clinical Chemistry 40, 20222025.CrossRefGoogle Scholar
Booth, S. L., Sokoll, L. J., O'Brien, M. E., Tucker, K., Dawson-Hughes, B. & Sadowski, J. A. (1995). Assessment of dietary phylloquinone intake and vitamin K status in postmenopausal women. European Journal of Clinical Nutrition 49, 832841.Google ScholarPubMed
Bushinsky, D. A. & Sessler, N. E. (1992). Critical role of bicarbonate in calcium release from bone. American Journal of Physiology 263, F510F515.Google ScholarPubMed
Calvo, M. S., Kumar, R. & Heath, H. (1988). Elevated secretion and action of serum parathyroid hormone in young adults consuming high phosphorus, low calcium diets assembled from common foods. Journal of Clinical Endocrinology and Metabolism 66, 823829.CrossRefGoogle ScholarPubMed
Calvo, M. S., Kumar, R. & Heath, H. (1990). Persistently elevated parathyroid hormone secretion and action in young women after four weeks of ingesting high phosphorous, low calcium diets. Journal of Clinical Endocrinology and Metabolism 70, 13341340.CrossRefGoogle ScholarPubMed
Chan, E., Ho, C., MacDonald, D., Ho, S. & Chan, R. (1992). Interrelationships between urinary sodium, calcium, hydroxyproline and serum PTH in healthy subjects. Acta Endocrinologica 127, 242245.Google ScholarPubMed
Chan, A., Poon, P., Chan, E., Fung, S. & Swaminathan, R. (1993). The effect of high sodium intake on bone mineral content in rats fed a normal calcium or low calcium diet. Osteoporosis International 3, 341344.CrossRefGoogle ScholarPubMed
Colwell, A., Russell, R. & Eastell, R. (1993). Factors affecting the assay of urinary 3-hydroxy pyridinium crosslinks of collagen as markers of bone resorption. European Journal of Clinical Investigation 23, 341349.CrossRefGoogle ScholarPubMed
Consensus Development Conference (1993). Diagnosis, prophylaxis and treatment of osteoporosis. American Journal of Medicine 94, 646650.Google Scholar
Delmas, P., Christiansen, C., Mann, K. & Price, P. (1990). Bone Gla protein (osteocalcin): assay standardization report. Journal of Bone and Mineral Research 5, 511.CrossRefGoogle ScholarPubMed
Delmas, P., Schlemmer, A., Gineyts, E., Riis, B. & Christiansen, C. (1991). Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. Journal of Bone and Mineral Research 6, 639644.CrossRefGoogle ScholarPubMed
Douglas, A., Robins, S. P., Hutchison, J., Porter, R., Stewart, A. & Reid, D. M. (1995). Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation. Bone 17, 1520.CrossRefGoogle ScholarPubMed
Driessens, F., Verbeeck, R., van Dijk, I. & Borggreven, J. (1987). Response of plasma calcium and phosphate to magnesium depletion. A review and its physiological interpretation. Magnesium Bulletin 9, 193201.Google Scholar
Ducy, P., Desbois, C., Boyce, B., Pinero, G., Story, B., Dunstan, C., Smith, E., Bonadio, J., Goldstein, S., Gundberg, C., Bradley, A. & Karsenty, G. (1996). Increased bone formation in osteocalcin-deficient mice. Nature 382, 448452.CrossRefGoogle ScholarPubMed
Eastell, R., Colwell, A., Hampton, L. & Reeve, J. (1997). Biochemical markers of bone resorption compared with estimates of bone resorption from radiotracer kinetic studies in osteoporosis. Journal of Bone and Mineral Research 12, 5965.CrossRefGoogle ScholarPubMed
Fledelius, C., Johnsen, A., Cloos, P., Bonde, M. & Qvist, P. (1997). Characterization of urinary degradation products derived from type I collagen. Journal of Biological Chemistry 272, 97559763.CrossRefGoogle ScholarPubMed
Garnero, P. & Delmas, P. (1993). Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. Journal of Clinical Endocrinology and Metabolism 77, 10461053.Google ScholarPubMed
Garnero, P., Grimaux, M., Demiaux, B., Preaudat, C., Seguin, P. & Delmas, P. D. (1992). Measurement of serum osteocalcin with a human-specific 2-site immunoradiometric assay. Journal of Bone and Mineral Research 7, 13891398.CrossRefGoogle Scholar
Garnero, P., Hausherr, E., Chapuy, M., Marcelli, C., Grandjean, H., Muller, C., Cormier, C., Breart, G., Meunier, P. & Delmas, P. (1996). Markers of bone resorption predict hip fracture in elderiy women: The EPIDOS prospective study. Journal of Bone and Mineral Research 11, 15311538.CrossRefGoogle ScholarPubMed
Gomez, B., Ardakani, S., Ju, J., Jenkins, D., Cerelli, M., Daniloff, G. & Kung, V. (1995). Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum. Clinical Chemistry 41, 15601566.CrossRefGoogle ScholarPubMed
Hannon, R., Blumsohn, A., Al-Dehaimi, A. & Eastell, R. (1995). The use of biochemical markers of bone turnover to monitor the skeletal response to hormone replacement therapy. Bone 16, Suppl. 1, 109S.Google Scholar
Hanson, D., Weis, M., Bollen, A., Maslan, S., Singer, F. & Eyre, D. (1992). A specific immunoassay for monitoring human bone resorption: quantitation of type I collagen cross-linked N-telopeptides in urine. Journal of Bone and Mineral Research 7, 12511258.CrossRefGoogle ScholarPubMed
Hassager, C., Jensen, L., Johansen, J., Riis, B., Melkko, J., Podenphant, J., Risteli, L., Christiansen, C. & Risteli, J. (1991). The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones. Metabolism 40, 205208.CrossRefGoogle ScholarPubMed
Hassager, C., Risteli, J., Risteli, L., Jensen, S. & Christiansen, C. (1992). Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women. Journal of Bone and Mineral Research 7, 13071311.CrossRefGoogle ScholarPubMed
Heaney, R. P. (1993). Nutritional factors in osteoporosis. Annual Review of Nutrition 13, 287316.CrossRefGoogle ScholarPubMed
Heaney, R. P. & Recker, R. R. (1982). Effects of nitrogen, phosphorus and caffeine on calcium balance in women. Journal of Laboratory and Clinical Medicine 99, 4655.Google ScholarPubMed
Hodges, S. J., Akesson, K., Vergnaud, P., Obrant, K. & Delmas, P. D. (1993). Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. Journal of Bone and Mineral Research 8, 12411245.CrossRefGoogle ScholarPubMed
Hodges, S. J., Pilkington, M. J., Shearer, M. J., Bitensky, L. & Chayen, J. (1990). Age-related changes in the circulating levels of congeners of vitamin K2, menaquinone-7 and menaquinone-8. Clinical Science 78, 6366.CrossRefGoogle ScholarPubMed
Knapen, M. H. J., Hamulyak, K. & Vermeer, C. (1989). The effect of vitamin K supplementation on circulating osteocalcin (bone gla protein) and urinary calcium excretion. Annals of Internal Medicine 111, 10011005.CrossRefGoogle ScholarPubMed
Knight, D. C. & Eden, J. A. (1995). Phytoestrogens – a short review. Maturitas 22, 167175.Google Scholar
Krane, S., Kantrowitz, F., Byrne, M., Pinell, S. & Singer, F. (1977). Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation. Journal of Clinical Investigation 59, 819827.CrossRefGoogle ScholarPubMed
Krieger, N. S., Sessler, N. E. & Bushinsky, D. A. (1992). Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro. American Journal of Physiology 262, F442F448.Google Scholar
Lemann, J. Jr, Gray, R. W. & Pleuss, J. A. (1989). Potassium bicarbonate, but not sodium bicarbonate, reduces urinary calcium excretion and improves calcium balance in healthy men. Kidney International 35, 688695.CrossRefGoogle ScholarPubMed
Lemann, J. Jr, Pleuss, J. A. & Gray, R. W. (1993). Potassium causes calcium retention in healthy adults. Journal of Nutrition 123, 16231626.Google Scholar
Lemann, J. Jr, Pleuss, J. A., Gray, R. W. & Hoffmann, R. G. (1991). Potassium administration reduces and potassium deprivation increases urinary calcium excretion in healthy adults. Kidney International 39, 973983.CrossRefGoogle ScholarPubMed
Lietz, G., Avenell, A. & Robins, S. P. (1997). Short-term effects of dietary sodium intake on bone metabolism in postmenopausal women measured using urinary deoxypyridinoline excretion. British Journal of Nutrition 78, 7382.CrossRefGoogle Scholar
McKane, W., Khosla, S., Risteli, J., Robins, S. P., Muhs, J. & Riggs, B. (1997). Role of estrogen deficiency in pathogenesis of secondary hyperparathyroidism and increased bone resorption in elderly women. Proceedings of the Association of American Physicians 109, 174180.Google Scholar
Melkko, J., Kauppila, S., Niemi, S., Risteli, L., Haukipuro, K., Jukkola, A. & Risteli, J. (1996). Immunoassay for intact amino-terminal propeptide of human type I procollagen. Clinical Chemistry 42, 947954.CrossRefGoogle ScholarPubMed
Melkko, J., Niemi, S., Risteli, L. & Risteli, J. (1990). Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen. Clinical Chemistry 36, 13281332.Google Scholar
Merle, B. & Delmas, P. D. (1990). Normal carboxylation of circulating osteocalcin (bone gla protein) in Paget's disease of bone. Bone and Mineral 11, 237245.CrossRefGoogle ScholarPubMed
Michaelsson, K., Holmberg, L., Mallmin, H., Wolk, A., Bergstrom, R. & Ljunghall, S. (1995). Diet, bone mass, and osteocalcin: A cross-sectional study. Calcified Tissue International 57, 8693.Google Scholar
Moro, L., Modricky, C., Rovis, L. & DeBernard, B. (1988). Determination of galactosyl hydroxylysine in urine as a means for the identification of osteoporotic women. Bone and Mineral 3, 271276.Google ScholarPubMed
Need, A. G., Morris, H. A., Cleghorn, D. B., Nichilo, D. D., Horowitz, M. & Nordin, B. E. C. (1991). Effect of salt restriction on urinary hydroxyproline excretion in postmenopausal women. Archives of Internal Medicine 151, 757759.Google Scholar
New, S. A. (1995). An epidemiological investigation into the influence of nutritional factors on bone mineral density and bone metabolism. PhD Thesis, University of Aberdeen.Google Scholar
New, S. A., Robins, S. P., Garton, M., Martin, J., Grubb, D., Bolton-Smith, C., Lee, S. & Reid, D. M. (1996). Effects of dietary and non-dietary factors on bone metabolism. Proceedings of the Nutrition Society 55, 12A.Google Scholar
Orum, O., Hansen, M., Jensen, C., Sorensen, H., Jensen, L., Horslev-Petersen, K. & Teisner, B (1996). Procollagen type I N-terminal propeptide (PINP) as an indicator of type I collagen metabolism: ELISA development, reference interval, and hypovitaminosis D induced hyperparathyroidism. Bone 19, 157163.Google Scholar
Parfitt, A. M., Mundy, G. R., Roodman, G. D., Hughes, D. F. & Boyce, B. F. (1996). A new model for the regulation of bone resorption with particular reference to the effects of bisphosphonates. Journal of Bone and Mineral Research 11, 150159.CrossRefGoogle Scholar
Pratt, D. A., Daniloff, Y., Duncan, A. & Robins, S. P. (1992). Automated analysis of the pyridinium crosslinks of collagen in tissue and urine using solid-phase extraction and reversed-phase high-performance liquid chromatography. Analytical Biochemistry 207, 168175.CrossRefGoogle ScholarPubMed
Price, C. (1993). Multiple forms of human serum alkaline phosphatase: detection and quantitation. Annals of Clinical Biochemistry 30, 355372.CrossRefGoogle ScholarPubMed
Price, P. A. & Nishimoto, S. K. (1980). Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma. Proceedings of the National Academy of Sciences USA 77, 22342238.CrossRefGoogle ScholarPubMed
Price, R., Fenton, S., Shearer, M. & Bolton-Smith, C. (1996). Daily and seasonal variation in phylloquinone (vitamin K1) intake in Scotland. Proceedings of the Nutrition Society 55, 244A.Google Scholar
Risteli, J., Niemi, S., Kauppila, S., Melkko, J. & Risteli, L. (1995). Collagen propeptides as indicators of collagen assembly. Acta Orthopaedica Scandinavica 266, Suppl., 183188.CrossRefGoogle ScholarPubMed
Risteli, L. & Risteli, J. (1993). Biochemical markers of bone metabolism. Annals of Medicine 25, 385393.CrossRefGoogle ScholarPubMed
Risteli, L., Risteli, J. & Moniz, C. (1993). Measuring collagen degradation. European Journal of Clinical Investigation 23, 339340.Google Scholar
Robins, S. P. (1982). Turnover and crosslinking of collagen. In Collagen in Health and Disease, pp. 160178 [Weiss, J. B. and Jayson, M. I. V., editors]. Edinburgh: Churchill Livingstone.Google Scholar
Robins, S. P. (1995). Collagen crosslinks in metabolic bone disease. Acta Orthopaedica Scandinavica 266, Suppl., 171175.Google Scholar
Robins, S. P., Black, D., Paterson, C. R., Reid, D. M., Duncan, A. & Seibel, M. J. (1991). Evaluation of urinary hydroxypyridinium crosslink measurements as resorption markers in metabolic bone diseases. European Journal of Clinical Investigation 21, 310315.CrossRefGoogle ScholarPubMed
Robins, S. P., Duncan, A. & Riggs, B. L. (1990). Direct measurement of free hydroxypyridinium crosslinks of collagen in urine as new markers of bone resorption in osteoporosis. In Osteoporosis 1990, pp. 465468 [Christiansen, C. and Overgaard, K., editors]. Copenhagen: Osteopress ApS.Google Scholar
Robins, S. P., Hamilton, N., Nicol, P., Boschitsch, E., Endler, T. & Seibel, M. J. (1994 a). Bone resorption rates in pre-, peri-, and post-menopausal women determined by direct immunoassay of deoxypyridinoline. Journal of Bone and Mineral Research 9, S278.Google Scholar
Robins, S. P., Woitge, H., Hesley, R., Ju, J., Seyedin, S. & Seibel, M. J. (1994 b). Direct, enzyme-linked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorption. Journal of Bone and Mineral Research 9, 16431649.CrossRefGoogle ScholarPubMed
Schwartz, R. & Reddi, A. (1979). Influence of magnesium depletion on matrix-induced endochondral bone formation. Calcified Tissue International 29, 1520.CrossRefGoogle ScholarPubMed
Sebastian, A., Harris, S. T., Ottaway, J. H., Todd, K. M. & Morris, R. C. Jr (1994). Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. New England Journal of Medicine 330, 17761781.CrossRefGoogle ScholarPubMed
Seibel, M. J., Robins, S. P. & Bilezikian, J. P. (1992). Urinary pyridinium crosslinks of collagen: specific markers of bone resorption in metabolic bone disease. Trends in Endocrinology and Metabolism 3, 263270.CrossRefGoogle ScholarPubMed
Seyedin, S., Kung, V., Daniloff, Y., Hesley, R., Gomez, B., Nielsen, L., Rosen, H. & Zuk, R. (1993). Immunoassay for urinary pyridinoline: the new marker of bone resorption. Journal of Bone and Mineral Research 8, 635641.Google Scholar
Shortt, C. & Flynn, A. (1990). Sodium-calcium inter-relationships with specific reference to osteoporosis. Nutrition Research Reviews 3, 101115.CrossRefGoogle ScholarPubMed
Szulc, P., Chapuy, M. C., Meunier, P. J. & Delmas, P. D. (1993). Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. Journal of Clinical Investigation 91, 17691774.Google Scholar
Teti, A., Blair, H. C., Schlesinger, P., Grano, M., Zambonin-Zallone, A., Kahn, A. J., Teitelbaum, S. L. & Hruska, K. A. (1989). Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures. Journal of Clinical Investigation 84, 773780.CrossRefGoogle ScholarPubMed
Thomas, A. (1988). Osteoporosis. Lancet i, 1002.Google Scholar
Trimmer, E. (1988). Osteoporosis. Lancet i, 177.CrossRefGoogle Scholar
Van Daele, P., Seibel, M. J., Burger, H., Hofman, A., Grobbee, D., van Leeuwen, J., Birkenhaeger, J. & Pols, H. (1996). Case-control analysis of bone resorption markers, disability and hip fracture risk: the Rotterdam study. British Medical Journal 312, 482483.CrossRefGoogle ScholarPubMed
Vergnaud, P., Garnero, P., Meunier, P. J., Breart, G., Kamihagi, K. & Delmas, P. D. (1997). Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS study. Journal of Clinical Endocrinology and Metabolism 82, 719724.Google Scholar
World Health Organization (1994). Assessment of fracture risk and its application to screening for osteoporosis. Technical Report Series no. 843. Geneva: WHO.Google Scholar