Public Health Nutrition

Biological and behavioural determinants

Peanut consumption and cardiovascular risk

Mina Ghadimi Nourana1 p1 c1, Masoud Kimiagara1, Alireza Abadia2, Majid Mirzazadeha3 and Gail Harrisona4

a1 Department of Human Nutrition, National Nutrition and Food Technology Research Institute, Shahid Beheshti University MC, Tehran, Iran

a2 Department of Social Medicine, School of Medicine, Shahid Beheshti University MC, Tehran, Iran

a3 Department of Urology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

a4 Department of Community Health Sciences, School of Public Health, University of California, Los Angeles, CA, USA


Objective We evaluated the effects of peanut consumption on lipid profiles, atherogenic index of plasma (AIP) and CHD risk in hypercholesterolaemic men.

Design Randomised crossover clinical trial.

Setting Participants were randomly assigned to two groups. They were asked to consume peanut supplements (about 77 g) with their habitual diet for 4 weeks.

Subjects Fifty-four hypercholesterolaemic men with total cholesterol (TC) concentrations between 200 and 350 mg/dl.

Results Compared with the habitual diet, peanut supplementation of the habitual diet significantly reduced TC/HDL cholesterol (HDL-C) ratio (mean 1 (se 0·3) P = 0·001) and LDL cholesterol (LDL-C)/HDL-C ratio (mean 0·7 (se 0·2); P = 0·001). Peanut consumption increased HDL-C (mean 6·1 (se 1·5) mg/dl; P < 0·001) and total antioxidant capacity (TAC) (mean 1·2 (se 0·6) U/mL P = 0·04). In addition, peanut consumption significantly reduced the AIP (mean 0·1 (se 0·03) P = 0·01) and CHD estimated risk over 10 years based on systolic and diastolic blood pressures (mean 1·4 % (se 0·5 %) P = 0·004 and mean 2·2 % (se 0·5 %) P < 0·001, respectively).

Conclusions Short-term peanut consumption might improve lipid profiles, the AIP and CHD risk in free-living hypercholesterolaemic men.

(Received February 10 2009)

(Accepted November 05 2009)

(Online publication December 22 2009)


c1 Corresponding author: Email

p1 Correspondence address: 1515 Woods Road, Apartment 205, Winston-Salem, NC 27106, USA