Epidemiology and Infection

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Epidemiology and Infection (2010), 138:1531-1541 Cambridge University Press
Copyright © Cambridge University Press 2010
doi:10.1017/S0950268810001366

Original Papers

Influenza

Pandemic (H1N1) 2009 influenza in the UK: clinical and epidemiological findings from the first few hundred (FF100) cases


E. McLEANa1, R. G. PEBODYa1 c1, C. CAMPBELLa1, M. CHAMBERLANDa1, C. HAWKINSa1, J. S. NGUYEN-VAN-TAMa2, I. OLIVERa3, G. E. SMITHa3, C. IHEKWEAZUa3, S. BRACEBRIDGEa3, H. MAGUIREa3, R. HARRISa1, G. KAFATOSa1, P. J. WHITEa1a4, E. WYNNE-EVANSa1, J. GREENa1, R. MYERSa1, A. UNDERWOODa1, T. DALLMANa1, T. WREGHITTa5, M. ZAMBONa1, J. ELLISa1, N. PHINa1, B. SMYTHa6, J. McMENAMINa7 and J. M. WATSONa1

a1 Health Protection Agency, Centre for Infections, London, UK
a2 University of Nottingham, UK
a3 Health Protection Agency, Local and Regional Services, UK
a4 MRC Centre for Outbreak Analysis & Modelling, Imperial College London, UK
a5 Health Protection Agency, Regional Microbiology Network, UK
a6 Public Health Agency for Northern Ireland, Belfast, UK
a7 Health Protection Scotland, Glasgow, UK
Article author query
mclean e [PubMed]  [Google Scholar]
pebody rg [PubMed]  [Google Scholar]
campbell c [PubMed]  [Google Scholar]
chamberland m [PubMed]  [Google Scholar]
hawkins c [PubMed]  [Google Scholar]
nguyen-van-tam js [PubMed]  [Google Scholar]
oliver i [PubMed]  [Google Scholar]
smith ge [PubMed]  [Google Scholar]
ihekweazu c [PubMed]  [Google Scholar]
bracebridge s [PubMed]  [Google Scholar]
maguire h [PubMed]  [Google Scholar]
harris r [PubMed]  [Google Scholar]
kafatos g [PubMed]  [Google Scholar]
white pj [PubMed]  [Google Scholar]
wynne-evans e [PubMed]  [Google Scholar]
green j [PubMed]  [Google Scholar]
myers r [PubMed]  [Google Scholar]
underwood a [PubMed]  [Google Scholar]
dallman t [PubMed]  [Google Scholar]
wreghitt t [PubMed]  [Google Scholar]
zambon m [PubMed]  [Google Scholar]
ellis j [PubMed]  [Google Scholar]
phin n [PubMed]  [Google Scholar]
smyth b [PubMed]  [Google Scholar]
mcmenamin j [PubMed]  [Google Scholar]
watson jm [PubMed]  [Google Scholar]

SUMMARY

The UK was one of few European countries to document a substantial wave of pandemic (H1N1) 2009 influenza in summer 2009. The First Few Hundred (FF100) project ran from April–June 2009 gathering information on early laboratory-confirmed cases across the UK. In total, 392 confirmed cases were followed up. Children were predominantly affected (median age 15 years, IQR 10–27). Symptoms were mild and similar to seasonal influenza, with the exception of diarrhoea, which was reported by 27%. Eleven per cent of all cases had an underlying medical condition, similar to the general population. The majority (92%) were treated with antiviral drugs with 12% reporting adverse effects, mainly nausea and other gastrointestinal complaints. Duration of illness was significantly shorter when antivirals were given within 48 h of onset (median 5 vs. 9 days, P=0·01). No patients died, although 14 were hospitalized, of whom three required mechanical ventilation. The FF100 identified key clinical and epidemiological characteristics of infection with this novel virus in near real-time.

(Accepted May 18 2010)

(Online publication July 01 2010)

Key Words:Influenza; pandemic

Correspondence:

c1 Author for correspondence: Dr R. Pebody, Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London, NW9 5EQ. (Email: Richard.Pebody@hpa.org.uk)


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