Fetal and Maternal Medicine Review

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Fetal and Maternal Medicine Review (2010), 21:225-241 Cambridge University Press
Copyright © Cambridge University Press 2010
doi:10.1017/S0965539510000082

Research Article

MARFAN SYNDROME AND PREGNANCY: CLINICAL IMPLICATIONS AND MANAGEMENT


ARIADNA C GRIGORIUa1, JACK COLMANa2, CANDICE K SILVERSIDESa3, RACHEL WALDa3, SAMUEL C SIUa4 and MATHEW SERMERa1 c1

a1 Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto.
a2 Department of Medicine, Mount Sinai Hospital, University of Toronto.
a3 Department of Medicine, University Health Network, University of Toronto.
a4 Department of Cardiology, Schulich School of Medicine and Dentistry, University of Western Ontario.
Article author query
grigoriu ac [PubMed]  [Google Scholar]
colman j [PubMed]  [Google Scholar]
silversides ck [PubMed]  [Google Scholar]
wald r [PubMed]  [Google Scholar]
siu sc [PubMed]  [Google Scholar]
sermer m [PubMed]  [Google Scholar]

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder that affects multiple organ systems, primarily the cardiovascular, ocular and skeletal. It is the most common inherited condition affecting the heart and the aorta, occurring in 1:5000–1:9800 people. There is no ethnic or gender predisposition; 20 to 35% of cases arise from de novo mutations.

Correspondence:

c1 Mathew Sermer, Mount Sinai Hospital, 600 University Avenue, Room 1007, Toronto, Ontario M5G 1×5, email address: MSermer@mtsinai.on.ca