Normal fetal growth and development depends on multiple molecular mechanisms that coordinate both placental and fetal development. Efforts to better understand fetal/placental growth dysregulation and fetal growth restriction (FGR) are now being driven by several findings that highlight the longterm impact of FGR on susceptibility to disease. The association of poor fetal growth to perinatal medical complications is well accepted but more recent data also show that FGR is linked to common, serious adult health problems. Several large-scale human epidemiological studies from diverse countries have shown that conditions such as coronary heart disease, hypertension, stroke, type 2 diabetes mellitus, adiposity, insulin resistance and osteoporosis are more prevalent in individuals with a history of low birthweight.
(Online publication June 03 2010)
c1 Rosanna Weksberg, Hospital for Sick Children, Division of Clinical and Metabolic Genetics, 525 University Avenue, Suite 940, 9th Floor, Toronto, Ontario M5G 1X8 Canada. Email address: firstname.lastname@example.org