a1 Lancaster University, Lancaster, UK
a2 Université d'Avignon, Avignon, France
a3 University of Chicago, Chicago, IL, USA
a4 University of Liverpool, Liverpool, UK
a5 Royal Preston Hospital, Preston, UK
A total of 969 isolates of Campylobacter jejuni originating in the Preston, Lancashire postcode district over a 3-year period were characterized using multi-locus sequence typing. Recently developed statistical methods and a genetic model were used to investigate temporal, spatial, spatio-temporal and genetic variation in human C. jejuni infections. The analysis of the data showed statistically significant seasonal variation, spatial clustering, small-scale spatio-temporal clustering and spatio-temporal interaction in the overall pattern of incidence, and spatial segregation in cases classified according to their most likely species-of-origin.
(Accepted February 09 2010)
(Online publication March 05 2010)