Epidemiology and Infection

Original Papers

Campylobacter infection

Spatio-temporal epidemiology of Campylobacter jejuni enteritis, in an area of Northwest England, 2000–2002

E. GABRIELa1a2 c1, D. J. WILSONa1a3, A. J. H. LEATHERBARROWa4, J. CHEESBROUGHa4, S. GEEa4, E. BOLTONa5, A. FOXa5, P. FEARNHEADa1, C. A. HARTa4 and P. J. DIGGLEa1

a1 Lancaster University, Lancaster, UK

a2 Université d'Avignon, Avignon, France

a3 University of Chicago, Chicago, IL, USA

a4 University of Liverpool, Liverpool, UK

a5 Royal Preston Hospital, Preston, UK

SUMMARY

A total of 969 isolates of Campylobacter jejuni originating in the Preston, Lancashire postcode district over a 3-year period were characterized using multi-locus sequence typing. Recently developed statistical methods and a genetic model were used to investigate temporal, spatial, spatio-temporal and genetic variation in human C. jejuni infections. The analysis of the data showed statistically significant seasonal variation, spatial clustering, small-scale spatio-temporal clustering and spatio-temporal interaction in the overall pattern of incidence, and spatial segregation in cases classified according to their most likely species-of-origin.

(Accepted February 09 2010)

(Online publication March 05 2010)

Correspondence:

c1 Author for correspondence: Dr E. Gabriel, IUT STID, Université d'Avignon, BP 1207, 84 911 Avignon Cedex 9, France. (Email: edith.gabriel@univ-avignon.fr)

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