International Psychogeriatrics

Research Article

The Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity of a revised assessment of neuropsychiatric symptoms in dementia

K. de Medeirosa1a2 c1, P. Roberta3, S. Gauthiera4, F. Stellaa5, A. Politisa6, J. Leoutsakosa2a15, F. Taraganoa7, J. Kremera8, A. Brugnoloa9, A. P. Porsteinssona10, Y. E. Gedaa11, H. Brodatya12, G. Gazdaga13, J. Cummingsa14 and C. Lyketsosa2a15 for the NPI-C Research Group

a1 The Copper Ridge Institute, Sykesville, Maryland, U.S.A.

a2 Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.

a3 Centre Mémoire de Ressources et de Recherche – CHU – Nice–Sophia Antipolis University, France

a4 McGill Center for Studies in Aging, Montreal, Canada

a5 UNESP – São Paulo State University, Biosciences Institute, Rio Claro, SP, Brazil

a6 Division of Geriatric Psychiatry, Egnition Hopsital, Athens Hospital, Athens, Greece

a7 CEMIC, University Hospital Dementia Research Unit, Buenos Aires, Argentina

a8 Institute Privado Kremer, Cordoba, Argentina

a9 Department of Neurosciences, DINOG, Genoa, Italy

a10 AD-CARE, University of Rochester School of Medicine and Dentistry, Rochester, New York, U.S.A.

a11 Mayo Clinic, Rochester, Minnesota, U.S.A.

a12 Dementia Collaborative Research Centre, University of South Wales, Sydney, Australia

a13 1st Department of Psychiatry and Psychiatric Rehabilitation, Jahn Ferenc Hospital, Budapest, Hungary

a14 Department of Neurology, University of California, Los Angeles, California, U.S.A.

a15 Department of Psychiatry, Johns Hopkins Bayview, Baltimore, Maryland, U.S.A.


Background: Neuropsychiatric symptoms (NPS) affect almost all patients with dementia and are a major focus of study and treatment. Accurate assessment of NPS through valid, sensitive and reliable measures is crucial. Although current NPS measures have many strengths, they also have some limitations (e.g. acquisition of data is limited to informants or caregivers as respondents, limited depth of items specific to moderate dementia). Therefore, we developed a revised version of the NPI, known as the NPI-C. The NPI-C includes expanded domains and items, and a clinician-rating methodology. This study evaluated the reliability and convergent validity of the NPI-C at ten international sites (seven languages).

Methods: Face validity for 78 new items was obtained through a Delphi panel. A total of 128 dyads (caregivers/patients) from three severity categories of dementia (mild = 58, moderate = 49, severe = 21) were interviewed separately by two trained raters using two rating methods: the original NPI interview and a clinician-rated method. Rater 1 also administered four additional, established measures: the Apathy Evaluation Scale, the Brief Psychiatric Rating Scale, the Cohen-Mansfield Agitation Index, and the Cornell Scale for Depression in Dementia. Intraclass correlations were used to determine inter-rater reliability. Pearson correlations between the four relevant NPI-C domains and their corresponding outside measures were used for convergent validity.

Results: Inter-rater reliability was strong for most items. Convergent validity was moderate (apathy and agitation) to strong (hallucinations and delusions; agitation and aberrant vocalization; and depression) for clinician ratings in NPI-C domains.

Conclusion: Overall, the NPI-C shows promise as a versatile tool which can accurately measure NPS and which uses a uniform scale system to facilitate data comparisons across studies.

(Received March 11 2010)

(Revised April 02 2010)

(Revised April 05 2010)

(Accepted April 08 2010)

(Online publication July 01 2010)


c1 Correspondence should be addressed to: Kate de Medeiros, The Copper Ridge Institute, 710 Obrecht Road, Sykesville, Maryland, 21784, U.S.A.. Phone: +1 (410) 552-3201; Fax: +1 (410) 552-0344. Email:

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