Hypertension is a key feature of the metabolic syndrome. Lifestyle and dietary changes may affect blood pressure (BP), but the knowledge of the effects of dietary fat modification in subjects with the metabolic syndrome is limited. The objective of the present study was to investigate the effect of an isoenergetic change in the quantity and quality of dietary fat on BP in subjects with the metabolic syndrome. In a 12-week European multi-centre, parallel, randomised controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to one of the four diets distinct in fat quantity and quality: two high-fat diets rich in saturated fat or monounsaturated fat and two low-fat, high-complex carbohydrate diets with or without 1·2 g/d of very long-chain n-3 PUFA supplementation. There were no overall differences in systolic BP (SBP), diastolic BP or pulse pressure (PP) between the dietary groups after the intervention. The high-fat diet rich in saturated fat had minor unfavourable effects on SBP and PP in males.
(Received June 01 2009)
(Revised November 30 2009)
(Accepted February 02 2010)
(Online publication March 05 2010)
† H. L. G. and I. M. F. G. contributed equally to this work.
Abbreviations: ANCOVA, analysis of covariance; BP, blood pressure; DBP, diastolic BP; HMUFA, high content of MUFA; HSFA, high content of SFA; LFHCC, low-fat, high-complex carbohydrate; PP, pulse pressure; SBP, systolic BP