British Journal of Nutrition

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British Journal of Nutrition (2010), 104:160-163 Cambridge University Press
Copyright © The Authors 2010

Short Communication

Dietary fat modifications and blood pressure in subjects with the metabolic syndrome in the LIPGENE dietary intervention study

Hanne L. Gulsetha1a2 c1, Ingrid M. F. Gjelstada1a2, Audrey C. Tierneya3, Danielle I. Shawa4, Olfa Helala5, Anneke M. J. v. Heesa6, Javier Delgado-Listaa7, Iwona Leszczynska-Golabeka8, Brita Karlströma9, Julie Lovegrovea4a10, Catherine Defoorta5, Ellen E. Blaaka6, Jose Lopez-Mirandaa7, Aldona Dembinska-Kieca8, Ulf Risérusa9, Helen M. Rochea3, Kåre I. Birkelanda1 and Christian A. Drevona2

a1 Hormone Laboratory, Department of Clinical Endocrinology, Faculty of Medicine, Oslo University Hospital Aker, University of Oslo, Trondheimsveien 235, N-0514 Oslo, Norway
a2 Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
a3 Nutrigenomics Research Group, UCD Conway Institute and School of Public Health, Population Science, University College Dublin, Dublin, Republic of Ireland
a4 Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading, UK
a5 INSERM, 476 Human Nutrition and Lipids, Faculty of Medicine, University Méditerranée Aix-Marseille 2, Marseille, France
a6 Department of Human Biology, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
a7 Lipid and Atherosclerosis Unit, Department of Medicine, School of Medicine, Reina Sofia University Hospital, Ciber Fisiopatologia Nutricion y Obesidad (CB06/03), Instituto Salud Carlos III, University of Cordoba, Cordoba, Spain
a8 Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
a9 Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
a10 Institute of Cardiovascular and Metabolic Research, University of Reading, Reading, UK
Article author query
gulseth hl [PubMed]  [Google Scholar]
gjelstad imf [PubMed]  [Google Scholar]
tierney ac [PubMed]  [Google Scholar]
shaw di [PubMed]  [Google Scholar]
helal o [PubMed]  [Google Scholar]
hees amj [PubMed]  [Google Scholar]
delgado-lista j [PubMed]  [Google Scholar]
leszczynska-golabek i [PubMed]  [Google Scholar]
karlström b [PubMed]  [Google Scholar]
lovegrove j [PubMed]  [Google Scholar]
defoort c [PubMed]  [Google Scholar]
blaak ee [PubMed]  [Google Scholar]
lopez-miranda j [PubMed]  [Google Scholar]
dembinska-kiec a [PubMed]  [Google Scholar]
risérus u [PubMed]  [Google Scholar]
roche hm [PubMed]  [Google Scholar]
birkeland ki [PubMed]  [Google Scholar]
drevon ca [PubMed]  [Google Scholar]


Hypertension is a key feature of the metabolic syndrome. Lifestyle and dietary changes may affect blood pressure (BP), but the knowledge of the effects of dietary fat modification in subjects with the metabolic syndrome is limited. The objective of the present study was to investigate the effect of an isoenergetic change in the quantity and quality of dietary fat on BP in subjects with the metabolic syndrome. In a 12-week European multi-centre, parallel, randomised controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to one of the four diets distinct in fat quantity and quality: two high-fat diets rich in saturated fat or monounsaturated fat and two low-fat, high-complex carbohydrate diets with or without 1·2 g/d of very long-chain n-3 PUFA supplementation. There were no overall differences in systolic BP (SBP), diastolic BP or pulse pressure (PP) between the dietary groups after the intervention. The high-fat diet rich in saturated fat had minor unfavourable effects on SBP and PP in males.

(Received June 01 2009)

(Revised November 30 2009)

(Accepted February 02 2010)

(Online publication March 05 2010)

Key Words:Metabolic syndrome; Diet; Fatty acids; Blood pressure; LIPGENE


c1 Corresponding author: Dr Hanne L. Gulseth, fax +47 22894432, email


† H. L. G. and I. M. F. G. contributed equally to this work.

Abbreviations: ANCOVA, analysis of covariance; BP, blood pressure; DBP, diastolic BP; HMUFA, high content of MUFA; HSFA, high content of SFA; LFHCC, low-fat, high-complex carbohydrate; PP, pulse pressure; SBP, systolic BP