Parasitology

Research Article

Metabolomic systems biology of trypanosomes

MICHAEL P. BARRETTa1 c1, BARBARA M. BAKKERa2 and RAINER BREITLINGa3

a1 Faculty of Biomedical and Life Sciences and Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United Kingdom

a2 Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

a3 Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands

SUMMARY

Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental perturbation, and to identify the targets of drugs. Here we discuss recent developments in metabolomic analysis, from the perspective of trypanosome research, highlighting remaining challenges and the most promising areas for future research.

(Received October 26 2009)

(Revised January 11 2010)

(Accepted January 11 2010)

(Online publication February 17 2010)

Correspondence:

c1 Corresponding author: Faculty of Biomedical and Life Sciences and Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United Kingdom. Tel: 0141-330-6904. Fax: 0141-330-4600. Email: m.barrett@bio.gla.ac.uk

Metrics