Epidemiology and Infection

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Epidemiology and Infection (2010), 138:1096-1099 Cambridge University Press
Copyright © Cambridge University Press 2009

Original Papers


Variation in the host ABO blood group may be associated with susceptibility to hepatitis C virus infection

R. BEHALa1, R. JAINa2, K. K. BEHALa1 and T. N. DHOLEa3 c1

a1 Department of Faculty of Advanced Studies in the Life Sciences, CSJM University, Kanpur, India
a2 Department of Pathology, GSVM Medical College, Kanpur, India
a3 Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Article author query
behal r [PubMed]  [Google Scholar]
jain r [PubMed]  [Google Scholar]
behal kk [PubMed]  [Google Scholar]
dhole tn [PubMed]  [Google Scholar]


This study aimed to determine the relationship between hepatitis C virus (HCV) infection and ABO/Rhesus blood groups, age and sex. A total of 20 000 patients who came to donate blood in the blood bank of GSVM Medical College, Kanpur were enrolled in the study. Demographic data recorded for each patient included age, sex and blood group. Blood samples were tested for anti-HCV antibodies and ABO/Rhesus blood group antigen typing was performed. The overall positive rate of anti-HCV was 0·34%. We found that seropositivity for HCV increased with age. Anti-HCV antibodies were detected in 1/765 women (0·13%), compared to 67/19 235 men (0·35%). Seroprevalence of HCV was found to be higher in blood group O individuals (0·42%) and lowest in blood group AB individuals (0·04%). The results of this study demonstrate that that HCV infection may not be related to age and sex but the possible association of blood group antigens with HCV infection cannot be ruled out.

(Accepted October 13 2009)

(Online publication December 14 2009)

Key Words:ABO blood group; blood donors; hepatitis C virus; risk factors; seroprevalence


c1 Author for correspondence: Professor T. N. Dhole, Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raibarelli Road, Lucknow, U.P., India 226014. (Email: tndhole@gmail.com)