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PRE-TERM PRE-LABOUR RUPTURE OF MEMBRANES AND THE ROLE OF AMNIOCENTESIS

Published online by Cambridge University Press:  15 March 2010

ANNA P KENYON*
Affiliation:
Elizabeth Garrett Anderson Institute for Women's Health, University College London, 86-96 Chenies Mews, London WCIE 6NX. Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, 235 Euston Rd, London NWI 2BU.
KHALIL N ABI-NADER
Affiliation:
Elizabeth Garrett Anderson Institute for Women's Health, University College London, 86-96 Chenies Mews, London WCIE 6NX. Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, 235 Euston Rd, London NWI 2BU.
PRANAV P PANDYA
Affiliation:
Fetal Medicine Unit, University College London Hospitals NHS Foundation Trust, 235 Euston Rd, London NWI 2BU.
*
Anna Kenyon, Elizabeth Garrett Anderson Institute for Women's Health, University College London, 86-96 Chenies Mews, London WCIE 6NX. Email address. anna.kenyon@ucl.ac.uk

Extract

Pre-labour premature rupture of membranes (PPROM) is defined as rupture of membranes more than 1 hour prior to the onset of labour at <37 weeks gestation. PPROM occurs in approximately 3% of pregnancies and is responsible for a third of all preterm births. Once membranes are ruptured prolonging the pregnancy has no maternal physical advantage but fetal morbidity and mortality are improved daily at early gestations: 19% of those infants born <25 weeks develop cerebral palsy (CP) and 28% have severe motor disability. Those infants born extremely pre term (<28 weeks) cost the public sector £75835 (95% CI £27906–145508) per live birth not to mention the emotional cost to the family. To prolong gestation is therefore the suggested goal: however how and why might we delay birth in those at risk?

Type
Research Article
Copyright
Copyright © Cambridge University Press 2010

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