Psychological Medicine
- Psychological Medicine / Volume 40 / Issue 06 / June 2010, pp 935-944
- Copyright © Cambridge University Press 2009
- DOI: http://dx.doi.org/10.1017/S0033291709991267 (About DOI), Published online: 15 September 2009
Original Articles
Prognostic value of cognitive functioning for global functional recovery in first-episode schizophrenia
C. González-Blancha1 c1, R. Perez-Iglesiasa1, G. Pardo-Garcíaa1, J. M. Rodríguez-Sáncheza1, O. Martínez-Garcíaa1, J. L. Vázquez-Barqueroa1 and B. Crespo-Facorroa1
a1 Psychiatry Research Unit of Cantabria, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), University Hospital ‘Marqués de Valdecilla’, Santander, Spain
Abstract
Background It has become widely accepted that cognitive deficits in schizophrenia are related to functional outcome. However, it remains to be seen whether these associations are relevant for predicting which cases will have a global functional recovery. In this study, we attempt to determine whether global functional recovery (integrating social and occupational outcomes) after first-episode schizophrenia (FES) can be predicted by cognitive variables.
Method A total of 131 FES patients with functional deficits (n=97) and functional recovery (n=34) as determined at 1-year follow-up were examined. Neuropsychological, sociodemographic, pre-morbid and clinical data at baseline were analysed using independent groups comparisons and a logistic regression method.
Results Sustained attention and negative symptoms emerged as significant predictors of good global functional outcome. Although the model revealed a high accuracy (91%) in the classification of patients with functional deficits, it was unacceptably low (26%) in the classification of patients with global functional recovery.
Conclusions The limitations found in the prediction of a favourable global functional outcome may well be an indication for a need to address the role of other factors not commonly included in longitudinal studies of long-term outcomes in schizophrenia.
(Received April 28 2009)
(Revised July 27 2009)
(Accepted August 06 2009)
(Online publication September 15 2009)
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Correspondence:
c1 Address for correspondence: Dr C. González-Blanch, Hospital Universitario ‘Marqués de Valdecilla’, Unidad de Investigación en Psiquiatría de Cantabria, Planta 2a, Edificio 2 de Noviembre Avda, Valdecilla s/n, 39008, Santander, Spain. (Email: cgblanch@terra.es)
