Journal of the International Neuropsychological Society

Research Articles

When “Crack walnuts” lies in different brain regions: Evidence from a voxel-based lesion-symptom mapping study

FABRIZIO PIRASa1a2 and PAOLA MARANGOLOa3 c1

a1 Laboratorio di Neuroimmagini, Fondazione IRCCS Santa Lucia, Rome, Italy

a2 Center for Research in Language, University of California, San Diego, California

a3 Dipartimento di Neuroscienze, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy

Abstract

Theories of lexical processing differ as to how multimorphemic words, such as compounds, are mentally processed. The most recent findings seem to support the dual route hypothesis, which assumes that complex words can be stored and retrieved either whole or by decomposition into their constituents. Despite great efforts to investigate the cognitive mechanisms involved in processing complex words, very little is known about how compounds are represented in the brain. The present study was designed to address this issue in a group of 20 left-hemispheric stroke patients who were submitted to four picture-naming tasks involving nouns, verbs, noun-noun (NN) and verb-noun (VN) compounds. To determine the brain lesions implicated in these tasks, we analyzed patients’ performances together with their lesions using Voxel-based Lesion Symptom Mapping (VLSM). Results showed that while NN involved the same temporal areas as nouns, VN (although they belong to the noun category) involved different fronto-temporal regions. This latter finding is discussed within the view that distinct mechanisms process the different constituents of complex words. (JINS, 2010, 16, 433–442.)

(Received July 22 2009)

(Reviewed January 04 2010)

(Accepted January 04 2010)

Correspondence:

c1 Correspondence and reprint requests to: Prof. Paola Marangolo, Dipartimento di Neuroscienze, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italia. E-mail: p.marangolo@univpm.it