Genetical Research



Review Article

Statistical design and the analysis of gene expression microarray data


M.  KATHLEEN KERR  a1 c1 and GARY  A. CHURCHILL  a1
a1 The Jackson Laboratory, Bar Harbor, Maine 04609 USA

Abstract

Gene expression microarrays are an innovative technology with enormous promise to help geneticists explore and understand the genome. Although the potential of this technology has been clearly demonstrated, many important and interesting statistical questions persist. We relate certain features of microarrays to other kinds of experimental data and argue that classical statistical techniques are appropriate and useful. We advocate greater attention to experimental design issues and a more prominent role for the ideas of statistical inference in microarray studies.


Correspondence:
c1 Corresponding author. The Jackson Laboratory, 600 Main Street, Box 303, Bar Harbor, ME 04609 USA.Tel : (207)-288-6000 x1281. Fax : (207)-288-6077.e-mail : mkk@jax.org.


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