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Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

Published online by Cambridge University Press:  23 December 2009

J. BRIAN de SOUZA ,
JULIUS C. R. HAFALLA ,
ELEANOR M. RILEY  and
KEVIN N. COUPER
J. BRIAN de SOUZA
Affiliation:
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT, UK Department of Immunology and Molecular Pathology, University College London Medical School, 46 Cleveland Street, LondonW1T 4JF, UK
JULIUS C. R. HAFALLA
Affiliation:
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT, UK
ELEANOR M. RILEY
Affiliation:
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT, UK
KEVIN N. COUPER*
Affiliation:
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT, UK
*
*Corresponding author: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT, UK. Tel: +44 207 927 2690. Fax: +44 207 927 2807. E-mail: kevin.couper@lshtm.ac.uk
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Summary

Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding the condition is severely hampered by the inability to study in detail, ante-mortem, the parasitological and immunological events within the brain that lead to the onset of clinical symptoms. Experimental murine models have been used to investigate the sequence of events that lead to cerebral malaria, but there is significant debate on the merits of these models and whether their study is relevant to human disease. Here we review the current understanding of the parasitological and immunological events leading to human and experimental cerebral malaria, and explain why we believe that studies with experimental models of CM are crucial to define the pathogenesis of the condition.

Keywords

cerebral malariamurine modelpathogenesis
Type
Review Article
Information
Parasitology , Volume 137 , Issue 5 , April 2010 , pp. 755 - 772
Copyright
Copyright © Cambridge University Press 2009

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