Cardiology in the Young

Review

Changing concepts of endocardial fibroelastosis

Paul R. Luriea1 c1

a1 Department of Pediatrics, Albany Medical College, New York, United States of America

Abstract

Endocardial fibroelastosis is not a disease but a reaction of the endocardium. I review the history of the term with emphasis on the gradual understanding of the many causes of this reaction. I include a comprehensive list of diseases or other cardiac stresses that authors have reported in association, and I try to explain the mechanism of the reaction. Although endocardial fibroelastosis is rare today, I issue a warning of a possible epidemic recrudescence of some of the associated diseases. My hope is for nosologic purity, therefore that outworn but surviving concepts will be firmly rejected.

(Received October 13 2009)

(Accepted January 10 2010)

(Online publication March 29 2010)

Correspondence:

c1 Correspondence to: P. R. Lurie, Department of Pediatrics, Albany Medical College, 334 State Street, Albany NY, 12210, United States of America. Tel: +518 436 0903; E-mail: plurie1@verizon.net