Psychological Medicine

Brief Communication

Genetic and environmental influences on anorexia nervosa syndromes in a population–based twin sample

K. L.  KLUMP  a1 c1, K. B.  MILLER  a1, P. K.  KEEL  a1, M.  McGUE  a1 and W. G.  IACONO  a1
a1 From the Department of Psychology, Michigan State University, East Lansing, MI; Department of Psychology, University of Minnesota, Minneapolis, MN; and Department of Psychology, Harvard University, Boston, MA, USA


Background. Genetic and environmental influences on broadly-defined anorexia nervosa (AN) syndrome were examined in a population-based twin sample.

Methods. AN syndrome was assessed in 672 female 17 year-old twins using structured interviews and a self-report questionnaire.

Results. Twenty-six probands with AN syndrome were identified. Biometrical model-fitting analyses indicated that genetic and non-shared environmental factors accounted for 74 % and 26 % of the variance in AN syndrome, respectively.

Conclusions. Findings support previous research indicating significant genetic and non-shared environmental influences on AN syndromes.

c1 Address for correspondence: Dr Kelly L. Klump, Department of Psychology, Michigan State University, 129 Psychology Research Building, East Lansing, MI 48824, USA.