Hostname: page-component-848d4c4894-ndmmz Total loading time: 0 Render date: 2024-04-30T12:40:58.688Z Has data issue: false hasContentIssue false
  • English
  • Français

Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome

Published online by Cambridge University Press:  22 February 2010

Mohammad Hashemi ,
Roya Kelishadi ,
Mahin Hashemipour ,
Afshin Zakerameli ,
Noushin Khavarian ,
Shohreh Ghatrehsamani  and
Parinaz Poursafa
Mohammad Hashemi
Affiliation:
Department of Cardiology, Isfahan University of Medical Sciences
Roya Kelishadi*
Affiliation:
Department of Pediatric Preventive Cardiology, Isfahan University of Medical Sciences, Isfahan Cardiovascular Research Center
Mahin Hashemipour
Affiliation:
Department of Pediatric Endocrinology, Isfahan University of Medical Sciences, Endocrine Research Center
Afshin Zakerameli
Affiliation:
Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran
Noushin Khavarian
Affiliation:
Department of Pediatric Preventive Cardiology, Isfahan University of Medical Sciences, Isfahan Cardiovascular Research Center
Shohreh Ghatrehsamani
Affiliation:
Department of Pediatric Preventive Cardiology, Isfahan University of Medical Sciences, Isfahan Cardiovascular Research Center
Parinaz Poursafa
Affiliation:
Department of Pediatric Preventive Cardiology, Isfahan University of Medical Sciences, Isfahan Cardiovascular Research Center
*
Correspondence to: Dr Roya Kelishadi MD, Associate Professor of Pediatrics, Department of Pediatric Preventive Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, PO Box 81465-1148, Isfahan, Iran. Tel: +98 311 3377881-8; Fax: +98 311 3373435; E-mail: Kelishadi@med.mui.ac.ir; kroya@aap.net
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives

This study, which to the best of our knowledge is the first of its kind, aimed to determine the acute and long-term effects of the consumption of grape and pomegranate juices on endothelium function in adolescents with metabolic syndrome, and to compare the effects of these two kinds of juices.

Methods

This randomised controlled clinical trial was conducted in 2008 among 30 adolescents, aged 12–15 years, with metabolic syndrome. Participants were randomly assigned to two groups of equal number; one group was asked to drink 18 millilitre per kilogram per day of natural grape juice and the other group was asked to drink 240 millilitre per day of natural pomegranate juice once daily for 1 month. Juices were homemade without any added sweetener. Basal brachial artery dimension and flow-mediated dilation as an index of endothelial function and endothelial-dependent dilation after receiving nitoglycerin spray were evaluated by high-resolution B mode ultrasonography before juice consumption, 4 hours and 30 days after regular daily consumption.

Results

Flow-mediated dilation at 90 seconds and after nitoglycerin significantly improved at 4 hours and at 1 month after drinking both kinds of juices, without significant difference between the two groups. The change at 1 month versus 4 hours was significant only in the grape juice group.

Conclusion

Daily consumption of diets rich in antioxidants might improve endothelial function in adolescents with metabolic syndrome. These effects began as soon as 4 hours after juice consumption. Such beneficial effects should be considered in dietary recommendations for the paediatric age group, notably in obese individuals.

Keywords

Antioxidantsendothelium functionyouthsobesity
Type
Original Articles
Information
Cardiology in the Young , Volume 20 , Issue 1 , February 2010 , pp. 73 - 77
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Kelishadi, R. Childhood overweight, obesity, and the metabolic syndrome in developing countries. Epidemiol Rev 2007; 29: 62–76.CrossRefGoogle ScholarPubMed
2.Woo, KS, Chook, P, Yu, CW, et al. Effect of diet and exercise on obesity related vascular dysfunction in children. Circulation 2004; 109: 1981–1986.CrossRefGoogle ScholarPubMed
3.Sola, S, Mir, M, Cheema, FA, et al. Irbesartan and lipoic acid impove endothelial function and reduce markers of inflammation in metabolic syndrome. Circulation 2005; 111: 343–348.CrossRefGoogle Scholar
4.Davis, N, Katz, S, Wilie-rosett, J. The effect of diet on endothelial function. Cardio Rev 2007; 15: 62–66.CrossRefGoogle ScholarPubMed
5.Hamdy, O, Ledburg, S, Mullooly, C, et al. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes 2003; 26: 2119–2125.Google ScholarPubMed
6.Esposito, K, Nappo, F, Giugliano, F, Giugliano, G, Marfella, R, Giugliano, D. Effect of dietary of dietary antioxidants on postprandial endothelial disfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr 2003; 77: 139–143.CrossRefGoogle Scholar
7.Beauloye, V, Zech, F, Tran, HT, Clapuyt, P, Maes, M, Brichard, SM. Determinants of early atherosclerosis in obese children and adolescents. J Clin Endocrinol Metab 2007; 92: 3025–3032.CrossRefGoogle ScholarPubMed
8.Hertog, MG, Feskens, EJ, Hollman, PC, Katan, MB, Kromhout, D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993; 342: 1007–1011.CrossRefGoogle ScholarPubMed
9.Vita, JA. Polyphenols and platelet function. Am J Clin Nutr 2005; 81: 2925–2975.CrossRefGoogle ScholarPubMed
10.Chou, EJ, Keevil, JG, Aseschlimann, S, Wiebe, DA, Folts, JD, Stein, JH. Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. Am J Cardiol 2001; 88: 553–555.CrossRefGoogle ScholarPubMed
11.Sumner, MD, Elliott-Eller, M, Weidner, G, et al. Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol 2005; 96: 810–814.CrossRefGoogle ScholarPubMed
12.Ford, ES, Li, C, Zhao, G, Pearson, WS, Mokdad, AH. Prevalence of the metabolic syndrome among US adolescents using the definition from the International Diabetes Federation. Diabetes Care 2008; 31: 587–589.CrossRefGoogle ScholarPubMed
13.WHO Physical Status: The Use Interpretation of Anthropometry. Report of a WHO Export Committee. TRS No. 854. World Health Organization, Geneva, 1992.Google Scholar
14.National high blood pressure education program working group on high blood pressure in children and adolescents. The forth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114: 555–576.CrossRefGoogle Scholar
15.Kelishadi, R, Hashemi, M, Mohammadifard, N, Asgary, S, Khavarian, N. Association of changes in oxidative and proinflammatory states with changes in vascular function after a lifestyle modification trial among obese children. Clin Chem 2008; 54: 147–1453.CrossRefGoogle ScholarPubMed
16.Stein, JH, Keevil, JG, Wiebe, DA, Aeschlimann, S, Folts, JD. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999; 100: 1050–1055.CrossRefGoogle ScholarPubMed
17.Folts, JD. Potential health benefits from the flavonoids in grape products on vascular disease. Adv Exp Med Biol 2002; 505: 95–111.CrossRefGoogle ScholarPubMed
18.Schwarzenberg, SJ, Sinaiko, AR. Obesity and inflammation in children. Paediatr Respir Rev 2006; 7: 239–246.CrossRefGoogle ScholarPubMed
19.Blüher, M. The inflammatory process of adipose tissue. Pediatr Endocrinol Rev 2008; 6: 24–31.Google ScholarPubMed
20.Kelishadi, R, Sharifi, M, Khosravi, A, Adeli, K. Relationship between C-reactive protein and atherosclerotic risk factors and oxidative stress markers among young persons 10–18 years old. Clin Chem 2007; 53: 456–464.CrossRefGoogle ScholarPubMed
21.Mietus-Snyder, M, Malloy, MJ. Endothelial dysfunction occurs in children with two genetic hyperlipidemias: improvement with antioxidant vitamin therapy. J Pediatr 1998; 133: 35–40.CrossRefGoogle ScholarPubMed
22.Engler, MM, Engler, MB, Malloy, MJ, et al. Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: endothelial assessment of risk from lipids in youth (EARLY) trial. Circulation 2003; 108: 1059–1063.CrossRefGoogle Scholar