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Comparative study of chronic copper poisoning in lambs and young goats

Published online by Cambridge University Press:  02 September 2010

G. Zervas ,
E. Nikolaou  and
A. Mantzios
G. Zervas
Affiliation:
Department of Animal Nutrition and Feeding, Agricultural University of Athens, lera Odos 75, GR-118 55, Athens, Greece
E. Nikolaou
Affiliation:
Department of Animal Nutrition and Feeding, Agricultural University of Athens, lera Odos 75, GR-118 55, Athens, Greece
A. Mantzios
Affiliation:
Department of Animal Nutrition and Feeding, Agricultural University of Athens, lera Odos 75, GR-118 55, Athens, Greece
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Abstract

Eighteen lambs (L) and 18 goats (G), 12 weeks of age, were allocated in equal numbers to three diets. The basal (B) diet had no added copper (Cu) while the other two had 30 or 60 mg added Cu per kg dry matter (DM) as CuSO4.5H2O. Lambs and goats were housed and fed individually. After 67 days, deaths from Cu toxicity occurred only in lambs from groups L-30 (basal diet + 30 mg Cu per kg DM) and L-60 (basal diet + 60 mg Cu per kg DM). The remaining lambs and all of the goats were slaughtered at 91 and 137 days respectively.

A decreased food intake and loss of weight were observed in some lambs towards the end of the experiment which appeared to be associated with an approaching haemolytic crisis. The additional dietary Cu had a positive effect on food conversion efficiency only in the early stages of the experiment in both lambs and goats. None of the goats died or lost weight.

Plasma Cu concentrations and serum glutamate oxalacetate transaminase and creatine kinase activities were elevated in lambs of groups L-30 and L-60 after 2 months, while in goats the concentrations were in normal ranges during the whole experimental period.

Additional dietary Cu increased significantly the Cu concentrations of liver, kidney, muscle, spleen, heart, brain, hair and faeces in both lambs and goats. Additional Cu decreased the fresh and dry liver weights of lambs and the liver to live weight ratio whereas the corresponding values for kidneys were increased. The differences between groups of goats in fresh or dry liver and kidney weights were not significant, though the fresh and dry liver weights tended to be higher in groups G·30 and G·60 compared with those in the group G·B.

The amount of Cu stored in the livers of the lambs was six to nine times higher than that of the goats. Differences in Cu storage between lambs and goats may be related to species differences in Cuutilization and hence resistance to Cu toxicity.

Keywords

coppergoatsgrowthlambspoisoning
Type
Research Article
Information
Animal Production , Volume 50 , Issue 3 , June 1990 , pp. 497 - 506
Copyright
Copyright © British Society of Animal Science 1990

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References

REFERENCES

Adam, S. E. I., Wasfi, I. A., and Magzoub, M. 1977. Chronic copper toxicity in Nubian goats. Journal of Comparative Pathology 87: 623–627.Google Scholar
Braude, R. 1967. Copper as a stimulant in pig feeding. World Review of Animal Production 3: (11), 69–82.Google Scholar
Buckley, W. T. and Tait, R. M. 1981. Chronic copper toxicity in lambs: a survey of blood constituent responses. Canadian Journal of Animal Science 61: 613–624.CrossRefGoogle Scholar
Clarke, E. G. C. and Clarke, M. L. 1975. Veterinary Toxicology. Bailliere Tindall, London.Google Scholar
Fincham, I. H. 1945. Copper poisoning in sheep. Veterinary Record 57: 581–587.Google Scholar
Gopinath, C., Hall, G. A. and Howell, J. McC. 1974. The effect of chronic Cu poisoning on the kidneys of sheep. Research in Veterinary Science 16: 57–69.CrossRefGoogle Scholar
Hill, R. 1977a. Copper toxicity I. British Veterinary Journal 133: 219–224.CrossRefGoogle ScholarPubMed
Hill, R. 1977b. Copper toxicity II. British Veterinary Journal 133: 365–373.Google Scholar
Hill, R. and Williams, H. Ll. 1965. The effects on intensively reared lambs of diets containing excess Cu. Veterinary Record 77: 1043–1045.CrossRefGoogle Scholar
Ishmael, J., Gopinath, G. and Howell, J. McC. 1971. Experimental chronic Cu toxicity in sheep. Research in Veterinary Science 12: 358–336.Google Scholar
MacPherson, A. and Hemingway, R. G. 1965. Effects of protein intake on the storage of copper in the liver of sheep. Journal of the Science of Food and Agriculture 16: 220–227.CrossRefGoogle Scholar
MacPherson, A. and Hemingway, R. G. 1969. The relative merits of various blood analyses and liver function tests in giving an early diagnosis of chronic copper poisoning in sheep. British Veterinary Journal 125: 213–221.Google Scholar
Mills, C. F., Dalgarno, A. C., Williams, R. B. and Quarterman, J. 1967. Zinc deficiency and the zinc requirements of calves and lambs. British Journal of Nutrition 21: 751–768.CrossRefGoogle ScholarPubMed
Mjor-Grimstud, M., Soli, N. E. and Norheim, G. 1980. The distribution of soluble Cu- and Zn- binding proteins in liver and kidney of chronic Cu poisoned goats. Ada Veterinaria Scandinavica 21: 578–586.CrossRefGoogle Scholar
Ogilvie, D. D. 1954. “Chronic” copper poisoning of sheep. Veterinary Record 66: 279–282.Google Scholar
Parris, E. C. C. and MacDonald, B. E. 1969. Effect of dietary protein source on copper toxicity in earlyweaned pigs. Canadian Journal of Animal Science 49: 215–222.Google Scholar
Ross, D. B. 1964. Chronic copper poisoning in lambs. Veterinary Record 76: 875–876.Google Scholar
Simpson, A. M., Mills, C. F. and McDonald, I. 1981. Tissue copper retention or loss in young growing cattle. Proceedings of the 4th International Symposium on Trace Element Metabolism in Man and Animals, pp. 133–136. Australian Academy of Science, Canberra.CrossRefGoogle Scholar
Smith, M. S. 1969. Responses of chicks to dietary supplements of copper sulphate. British Poultry Science 10: 97–108.CrossRefGoogle Scholar
Soli, N. E. and Froslie, A. 1977. Chronic Cu poisoning in sheep. I. The relationship of methaemoglobinaemia to Heinz body formation and haemolysis during the terminal crisis. Acta Pharmacologica et Toxicologica 169–177.Google Scholar
Soli, N. E. and Nafstad, I. 1978. Effects of daily oral administration of Cu to goats. Acta Veterinaria Scandinavica 19: 561–568.CrossRefGoogle Scholar
Suttle, N. F. 1978. Determining the Cu requirements of cattle by means of an intravenous repletion technique. Proceedings of the 3rd International Symposium on Trace Element Metabolism in Man and Animals, pp. 437–480. Freising-Weihenstephan: Technische, Universitat Munchen.Google Scholar
Suttle, N. F. and Field, A. C. 1983. Effects of dietary supplements of thiomolybdate on Cu and Mo metabolism in sheep. Journal of Comparative Pathology 93: 379–389.CrossRefGoogle Scholar
Thompson, R. M. and Todd, J. R. 1974. Muscle damage in chronic Cu poisoning of sheep. Research Veterinary Science 16: 97–99.Google Scholar
Todd, J. R. 1969. Chronic copper toxicity of ruminants. Proceedings of the Nutrition Society 28: 189–198.Google Scholar
Todd, J. R. and Thompson, R. H. 1963. Studies of Chronic Cu poisoning. II. Biochemical studies on the blood of sheep during the haemolytic crisis. British Veterinary Journal 119: 161–173.CrossRefGoogle Scholar
Underwood, E. J. 1977. Trace Elements in Human and Animal Nutrition. 4th ed. Academic Press, New York.Google Scholar
Woolliams, J. A., Suttle, N. F., Wiener, G., Field, A. C. and Woolliams, C. 1983. The long-term accumulation and depletion of copper in the liver of different breeds of sheep fed diets of differing copper content. Journal of Agricultural Science, Cambridge 100: 441–449.Google Scholar
Zervas, G. 1983. The prevention of Cu deficiency in ruminants by means of soluble glass rumen bullets. Ph.D. Thesis, Leeds University.Google Scholar