Hostname: page-component-7c8c6479df-94d59 Total loading time: 0 Render date: 2024-03-28T04:57:51.127Z Has data issue: false hasContentIssue false

Infection with influenza A/Victoria virus in Houston families, 1976

Published online by Cambridge University Press:  25 March 2010

L. H. Taber
Affiliation:
Influenza Research Center, 1200 Moursund Avenue, Houston, Texas 77030
A. Paredes
Affiliation:
Departments of Paediatrics, 1200 Moursund Avenue, Houston, Texas 77030
W. P. Glezen
Affiliation:
Microbiology and Immunology, 1200 Moursund Avenue, Houston, Texas 77030
R. B. Couch
Affiliation:
Baylor College of Medicine, 1200 Moursund Avenue, Houston, Texas 77030
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In 1976, an epidemic caused by infections with an influenza virus antigenically similar to A/Victoria/75 (H3N2) occurred in Houston, Texas. During this outbreak, 37 families (155 members) enrolled in the Houston Family Study were under observation. The families lived throughout the metropolitan area (Houston, Texas), and were representative of low income groups. The overall frequency of infection in family members was 27·7%. The frequency of infection was the highest for infants under one year of age and for their older siblings, 14 (37·8%) of 37 and 17 (33·3%) of 51, respectively. Eighteen (48·6%) of the 37 families had at least one infected member. Twelve of the 18 ‘infected’ families had school aged children, whereas only three of the 19 ‘non-infected’ families had school aged children (P < 0·01). These infected families were also larger and had increased household density (persons/rooms). The levels of pre-existing HI antibodies to A/Victoria/75 and A/Port Chalmers/73 were inversely related to frequencies of infection and illness associated with A/Victoria/75 virus. Three children required hospitalization as direct consequence of their infection with this H3N2 influenza virus. Antibody response to infection was related to previous experience with antigenically-related influenza A (H3N2) viruses according to Francis', ‘doctrine of original antigenic sin.’

Type
Research Article
Copyright
Copyright © Cambridge University Press 1981

References

REFERENCES

Baxter, B. D., Couch, R. B., Greenberg, S. B. & Kasel, J. A. (1977). Maintenance of viability and comparison of identification methods for influenza and respiratory viruses of humans. Journal of Clinical Microbiology 6, 1922.CrossRefGoogle ScholarPubMed
Davenport, F. M., Hennessy, A. V., Bernstein, S. H., Harper, O. F. & Klingensmith, W. H. (1955). Comparative incidence of influenza A-Prime in 1953 in completely vaccinated and unvaccinated Military Groups. American Journal of Public Health 45, 1138–46.CrossRefGoogle ScholarPubMed
Dowdle, W. A., Kendal, A. P., & Noble, G. R. (1979). Influenza viruses. Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections (ed. Lennette, E. H. and Schmidt, N. J.), pp. 598605. American Public Health Association.Google Scholar
Dunn, F. L., Carey, D. E., Cohen, A., & Martin, J. D. (1959). Epidemiologic studies of Asian influenza in Louisiana parish. American Journal of Hygiene 70, 351–71.Google ScholarPubMed
Farnik, J. & Bruj, J. (1966). An outbreak of influenza A2 in a population with a known antibody profile. Journal of Infectious Diseases 116, 425–8.CrossRefGoogle Scholar
Francis, T. Jr. (1955). The current status of the control of influenza. Annals Internal Medicine 43, 534–8.Google ScholarPubMed
Francis, T., Salk, J. E. & Brace, W. M. (1946). The protective effect of vaccination against epidemic influenza B. Journal of the American Medical Association 131, 275–8.CrossRefGoogle ScholarPubMed
Galbraith, A. W., Oxford, J. S., Schild, G. C. & Watson, G. I. (1969 a). Protective Effect of 1-Adamantanamine Hydrochloride on Influenza A 2 Infections in the Family Environment. A Controlled Double-blind Study. Lancet i, 1026–8.CrossRefGoogle Scholar
Galbraith, A. W., Oxford, J. S., Schild, G. C. & Watson, G. I. (1969 b). Study of 1-Adamantanamine Hydrochloride Used Prophylactically During the Hong Kong Influenza Epidemic in the Family Environment. Bulletin World Health Organization 41, 677–82.Google Scholar
Glezen, W. P. & Couch, R. B. (1978). Interpandemic influenza in the Houston Area, 1974–76. The New England Journal of Medicine 298, 587–92.CrossRefGoogle ScholarPubMed
Glezen, W. P., Paredes, A. & Taber, L. H. (1980). Influenza in children: relationship to other respiratory agents. Journal of American Medical Association 243, 1345–9.CrossRefGoogle ScholarPubMed
Green, R. H. (1959). Asian influenza in New Haven, 1957–1958: an epidemiological survey. Yale Journal of Biology and Medicine 32, 3343.Google ScholarPubMed
Greenberg, S. B., Couch, R. B. & Kasel, J. A. (1974). An outbreak of an influenza type A variant in a closed population: the effect of homologous and heterologous antibody on infection and illness. American Journal of Epidemiology 100, 209–15.CrossRefGoogle Scholar
Hall, C. B. & Douglas, R. G. Jr. (1975). Clinically useful method for the isolation of respiratory syncytial virus. Journal of Infectious Diseases 131, 15.CrossRefGoogle ScholarPubMed
Hobson, D., Curry, R. L. & Beare, A. S. (1973). Hemagglutination-Inhibiting Antibody Titres as a Measure of Protection Against Influenza in Man. Symposia Series in Immunobiological Standardization 20, 164–7.Google Scholar
Hope-Simpson, R. E. (1970). First Outbreak of Hong Kong Influenza in a General Practice Population in Great Britain. A Field and Laboratory Study. British Medical Journal 3, 74–7.CrossRefGoogle Scholar
Jennings, L. & Miles, J. (1978). A study of acute respiratory disease in the community of Port Chalmers. II. Influenza A/Port Chalmers/1/73: intrafamilial spread and the effect of antibodies to the surface antigens. Journal of Hygiene 81, 6775.CrossRefGoogle Scholar
Jordan, W. S. Jr. (1960). The mechanism of spread of Asian influenza. American Review of Respiratory Diseases 83, part 2, 2935.Google Scholar
Jordan, W. S., Denny, F. W., Badger, G. F., Curtiss, C., Dingle, J. H., Oseasohn, R. & Stevens, D. A. (1958). A study of illness in a group of Cleveland families. XVII. The occurrence of Asian influenza. American Journal of Hygiene 68, 190212.Google Scholar
Meiklejohn, G., Kempe, C. H., Thalman, W. G. & Lennette, E. H. (1952). Evaluation of monovalent influenza vaccines. II. Observations during an influenza A-prime epidemic. American Journal of Hygiene 55, 1221.Google ScholarPubMed
Philip, R. N., Bell, J. A., Davis, D. J., Beem, M. O., Beigelman, P. M., Engler, J. I., Mellin, G. W., Johnson, J. H. & Lerner, A. M. (1961). Epidemiologic studies on influenza in familial and general population groups, 1951–1956. American Journal of Hygiene 73, 123–37.Google ScholarPubMed
Puck, J. M., Glezen, W. P., Frank, A. L. & Six, H. R. (1980). Protection of infants from influenza A infection by transplacental antibody. Journal of Infectious Diseases (In the Press.)CrossRefGoogle Scholar
Rosenstock, I. M. (1960). The impact of Asian influenza on community life. Public Health Service Publication 766, 3840.Google Scholar
Suguira, A., Yanagawa, H., Enomoto, C., Ueda, M., Tobita, K., Matsuzaki, N., Suzuki, D., Nakaya, R. & Shigematsu, I. (1970). A field trial for evaluation of the prophylactic effect on influenza vaccine containing inactivated A2/Hong Kong and B influenza viruses. Journal of Infectious Diseases 122, 472–8.CrossRefGoogle Scholar