British Journal of Nutrition

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British Journal of Nutrition (2010), 103:833-841 Cambridge University Press
Copyright © The Authors 2009

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Metabolism and Metabolic Studies

Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males

Lesley L. Moiseya1, Lindsay E. Robinsona1 and Terry E. Grahama1 c1

a1 Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1
Article author query
moisey ll [PubMed]  [Google Scholar]
robinson le [PubMed]  [Google Scholar]
graham te [PubMed]  [Google Scholar]


Caffeine and caffeinated coffee (CC) elicit acute insulin insensitivity when ingested before a carbohydrate load. The effects of CC on glucose tolerance and insulin sensitivity when co-ingested with a high carbohydrate meal and on postprandial metabolism of a subsequent (second) carbohydrate load have not been studied. In a randomised, crossover design, ten healthy males ingested either CC (5 mg caffeine/kg body weight), decaffeinated coffee (DC) or water (W; equal volume) co-ingested with a high glycaemic index cereal followed 3 h later by a 75 g oral glucose tolerance test. After the initial meal, insulin area under the curve (AUC) and insulin sensitivity index did not differ between treatments, although glucose AUC for CC (107 (sem 18) mmol/l × 3 h) and DC (74 (sem 15) mmol/l × 3 h) was greater than W ( − 0·2 (sem 29) mmol/l × 3 h, P < 0·05). After the second carbohydrate load, insulin AUC for CC was 49 % and 57 % greater (P < 0·01) than for DC and W, respectively. Despite the greater insulin response, glucose AUC for CC (217 (sem 24) mmol/l × 2 h) was greater than both DC (126 (sem 11) mmol/l × 2 h, P = 0·01) and W (55 (sem 34) mmol/l × 2 h, P < 0·001). Insulin sensitivity index after the second meal was lower after CC (8·2 (sem 0·9)) compared with both DC (12·4 (sem 1·2), P < 0·01) and W (13·4 (sem 1·4), P < 0·001). Co-ingestion of CC with one meal resulted in insulin insensitivity during the postprandial phase of a second meal in the absence of further CC ingestion. Thus, CC may play a role in daily glycaemic management.

(Received December 12 2008)

(Revised August 03 2009)

(Accepted September 14 2009)

(Online publication November 05 2009)

Key Words:Coffee; Caffeine; Insulin sensitivity; Oral glucose tolerance test


c1 Corresponding author: Dr Terry E. Graham, fax +1 519 763 5902, email


Abbreviations: AUC, area under the curve; CC, caffeinated coffee; DC, decaffeinated coffee; OGTT, oral glucose tolerance test; T2DM, type 2 diabetes; W, water