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Comparison of social cognitive functioning in schizophrenia and high functioning autism: more convergence than divergence

Published online by Cambridge University Press:  12 August 2009

S. M. Couture*
Affiliation:
University of North Carolina-Chapel HillDepartment of Psychology, NC, USA
D. L. Penn
Affiliation:
University of North Carolina-Chapel HillDepartment of Psychology, NC, USA University of North Carolina-Chapel HillDepartment of Psychiatry, NC, USA
M. Losh
Affiliation:
University of North Carolina-Chapel HillDepartment of Psychiatry, NC, USA Neurodevelopmental Disorders Research Center (NDRC) in Chapel Hill, NC, USA
R. Adolphs
Affiliation:
California Institute of Technology in Pasadena, CA, USA
R. Hurley
Affiliation:
Neurodevelopmental Disorders Research Center (NDRC) in Chapel Hill, NC, USA
J. Piven
Affiliation:
University of North Carolina-Chapel HillDepartment of Psychiatry, NC, USA Neurodevelopmental Disorders Research Center (NDRC) in Chapel Hill, NC, USA
*
*Address for correspondence: Dr S. M. Couture, Department of Psychology, University of Maryland College Park, 1123M Biology-Psychology Building, College Park, MD20742S, USA. (Email: scouture@psyc.umd.edu)

Abstract

Background

Individuals with schizophrenia and individuals with high-functioning autism (HFA) seem to share some social, behavioral and biological features. Although marked impairments in social cognition have been documented in both groups, little empirical work has compared the social cognitive functioning of these two clinical groups.

Method

Forty-four individuals with schizophrenia, 36 with HFA and 41 non-clinical controls completed a battery of social cognitive measures that have been linked previously to specific brain regions.

Results

The results indicate that the individuals with schizophrenia and HFA were both impaired on a variety of social cognitive tasks relative to the non-clinical controls, but did not differ from one another. When individuals with schizophrenia were divided into negative symptom and paranoid subgroups, exploratory analyses revealed that individuals with HFA may be more similar, in terms of the pattern of social cognition impairments, to the negative symptom group than to the paranoia group.

Conclusions

Our findings provide further support for similarities in social cognition deficits between HFA and schizophrenia, which have a variety of implications for future work on gene–brain–behavior relationships.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2009

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References

Abdi, Z, Sharma, T (2004). Social cognition and its neural correlates in schizophrenia and autism. CNS Spectrums 9, 335343.CrossRefGoogle ScholarPubMed
Adolphs, R (2002). Recognizing emotion from facial expressions: psychological and neurological mechanisms. Behavioral and Cognitive Neuroscience Reviews 1, 2162.CrossRefGoogle ScholarPubMed
Adolphs, R, Tranel, D (2003). Amygdala damage impairs emotion recognition from scenes only when they contain facial expressions. Neuropsychologia 41, 12811289.CrossRefGoogle ScholarPubMed
Adolphs, R, Tranel, D, Damasio, AR (1998). The human amygdala in social judgment. Nature 393, 470474.CrossRefGoogle ScholarPubMed
Autism Genome Project Consortium, Szatmari, P, Paterson, AD, Zwaigenbaum, L, Roberts, W, Brian, J, Lui, XQ, Vincent, JB, Skaug, JL, Thompson, AP, Senman, L, Feuk, L, Oizn, C, Bryson, SE, Jones, MB, Marshall, CR, Scherer, SW, Vieland, VJ, Bartlett, C, Mangin, LV, Goedken, R, Segre, A, Pericak-Vance, MA, Cuccaro, ML, Gilbert, JR, Wright, HH, Abramson, RK, Betancur, C, Bourgeron, T, Gillberg, C, Leboyer, M, Buxbaum, JD, David, KL, Hollander, E, Silverman, JM, Hallmayer, J, Lotspeich, L, Sutcliffe, JS, Haines, JL, Folstein, SE, Piven, J, Wassink, TH, Sheffield, V, Geschwind, DH, Bucan, M, Brown, WT, Cantor, RM, Constantino, JN, Gilliam, TC, Herbert, M, Lejonchere, C, Ledbetter, DH, Lese-Martin, C, Miller, J, Nelson, S, Samango-Sprouse, CA, Spence, S, State, M, Tanzi, RE, Coon, H, Dawson, G, Devlin, B, Estes, A, Flodman, P, Klei, L, McMahon, WM, Minshew, N, Munson, J, Korvatska, E, Rodier, PM, Schellenberg, GD, Smith, M, Spence, MA, Stodgell, C, Tepper, PG, Wijsman, EM, Yu, CE, Rogé, B, Montoulan, C, Wittemeyer, K, Poustka, A, Felder, B, Klauck, SM, Schuster, C, Poustka, F, Bölte, S, Feineis-Matthews, S, Herbrecht, E, Schmötzer, G, Tsiantis, J, Papanikolaou, K, Maestrini, E, Bacchelli, E, Blasi, F, Carone, S, Toma, C, Van Engeland, H, de Jonge, M, Kemner, C, Koop, F, Langemeijer, M, Hijmans, C, Staal, WG, Baird, G, Bolton, PF, Rutter, ML, Weisblatt, E, Green, J, Aldred, C, Wilkinson, JA, Pickles, A, Le Couteur, A, Berney, T, McConachie, H, Bailey, AJ, Francis, K, Honeyman, G, Hutchinson, A, Parr, JR, Wallace, S, Monaco, AP, Barnby, G, Kobayashi, K, Lamb, JA, Sousa, I, Sykes, N, Cook, EH, Guter, SJ, Leventhal, BL, Salt, J, Lord, C, Corsello, C, Hus, V, Weeks, DE, Volkmar, F, Tauber, M, Fombonne, E, Shih, A, Meyer, KJ (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics 39, 319328.Google ScholarPubMed
Baron-Cohen, S, O'Riordan, M, Stone, V, Jones, R, Plaisted, K (1999 a). Recognition of faux pas by normally developing children with Asperger syndrome or high functioning autism. Journal of Autism and Developmental Disorders 29, 407418.CrossRefGoogle ScholarPubMed
Baron-Cohen, S, Ring, H, Wheelwright, S, Bullmore, E, Brammer, M, Simmons, A, Williams, SCR (1999 b). Social intelligence in the normal and autistic brain: an fMRI study. European Journal of Neuroscience 11, 18911998.CrossRefGoogle Scholar
Baron-Cohen, S, Wheelwright, S, Hill, J, Raste, Y, Plumb, I (2001). The ‘Reading the Mind in the Eyes’ Test revised version: a study with normal adults and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry 42, 241251.CrossRefGoogle ScholarPubMed
Bellugi, U, Adolphs, R, Cassady, C, Chiles, M (1999). Towards the neural basis for hypersociability in a genetic syndrome. Neuroreport 10, 16531657.CrossRefGoogle Scholar
Bölte, S, Poustka, F (2003). The recognition of facial affect in autistic and schizophrenic subjects and their first-degree relatives. Psychological Medicine 33, 907915.CrossRefGoogle ScholarPubMed
Bonda, E, Petrides, M, Ostry, D, Evans, A (1996). Specific involvement of human parietal systems and the amygdala in the perception of biological motion. Journal of Neuroscience 16, 37373744.CrossRefGoogle ScholarPubMed
Brune, M (2005). ‘Theory of mind’ in schizophrenia: a review of the literature. Schizophrenia Bulletin 31, 2142.CrossRefGoogle ScholarPubMed
Brunet, E, Sarfati, Y, Hardy-Boyle, M (2003). Reasoning about physical causality and other's intentions in schizophrenia. Cognitive Neuropsychiatry 8, 129139.CrossRefGoogle ScholarPubMed
Bryson, G, Bell, MD, Lysaker, PH (1997). Affect recognition in schizophrenia: a function of global impairment or a specific cognitive deficit. Psychiatry Research 71, 105113.CrossRefGoogle ScholarPubMed
Celani, G, Battacchi, MW, Arcidiacono, L (1999). The understanding of the emotional meaning of facial expressions in people with autism. Journal of Autism and Developmental Disorders 29, 5766.CrossRefGoogle ScholarPubMed
Couture, SM, Penn, DL, Addington, J, Woods, SW, Perkins, DO (2008). Assessment of social judgments and complex mental states in the early phases of psychosis. Schizophrenia Research 100, 237241.CrossRefGoogle ScholarPubMed
Couture, SM, Penn, DL, Roberts, DL (2006). The functional significance of social cognition in schizophrenia: a review. Schizophrenia Bulletin 32, S44S63.CrossRefGoogle ScholarPubMed
Craig, JS, Hatton, C, Craig, FB, Bentall, RP (2004). Persecutory beliefs, attributions and theory of mind: comparison of patients with paranoid delusions, Asperger's syndrome and healthy controls. Schizophrenia Research 69, 2933.CrossRefGoogle ScholarPubMed
Crespi, B, Badcock, C (2008). Psychosis and autism as diametrical disorders of the social brain. Behavioral and Brain Sciences 31, 241320.CrossRefGoogle ScholarPubMed
Edwards, J, Jackson, H, Pattison, PE (2002). Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clinical Psychology Review 22, 789832.CrossRefGoogle ScholarPubMed
First, MB, Spitzer, RL, Gibbon, M, Williams, JBW (1995). Structured Clinical Interview for DSM-IV Axis I Disorders – Patient Edition (SCID-I/P, Version 2.0). Biometrics Research Department, New York State Psychiatric Institute: New York.Google Scholar
Friedman, JM, Baross, A, Delaney, AD, Ally, A, Arbour, L, Asano, J, Bailey, DK, Barber, S, Birch, P, Brown-John, M, Cao, M, Chan, S, Charest, DL, Farnoud, N, Fernandes, N, Flibotte, S, Go, A, Gibson, WT, Holt, RA, Jones, SJM, Kennedy, GC, Krzywinski, M, Langlois, S, Li, HI, McGillivray, BC, Nayar, T, Pugh, TJ, Rajcan-Separovic, E, Schein, JE, Schnerch, A, Siddiqui, A, Van Allen, MI, Wilson, G, Yong, S, Zahir, F, Eydoux, P, Marra, MA (2006). Oligonucleotide microarray analysis of genomic imbalance in children with mental retardation. American Journal Human Genetics 79, 500513.CrossRefGoogle ScholarPubMed
Frith, CD, Corcoran, R (1996). Exploring ‘theory of mind’ in people with schizophrenia. Psychological Medicine 26, 521530.CrossRefGoogle ScholarPubMed
Gottesman, II, Gould, TD (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry 160, 636645.CrossRefGoogle ScholarPubMed
Grant, C, Addington, J, Addington, D (2001). Social functioning in first- and multi-episode schizophrenia. Canadian Journal of Psychiatry 46, 746749.CrossRefGoogle Scholar
Green, J, Gilchrist, A, Burton, D, Cox, A (2000). Social and psychiatric functioning in adolescents with Asperger syndrome compared with conduct disorder. Journal of Autism and Developmental Disorders 30, 279293.CrossRefGoogle ScholarPubMed
Heberlein, AS, Adolphs, R, Tranel, D, Damasio, H (2004). Cortical regions for judgments of emotions and personality traits from point-light walkers. Journal of Cognitive Neuroscience 16, 11431158.CrossRefGoogle ScholarPubMed
Herold, R, Tenyi, T, Lenard, K, Trixler, M (2002). Theory of mind deficit in people with schizophrenia during remission. Psychological Medicine 32, 11251129.CrossRefGoogle ScholarPubMed
Kaland, N, Moller-Neilsen, A, Callesen, K, Mortensen, EL, Gottlieb, D, Smith, L (2002). A new ‘advanced’ test of theory of mind: evidence from children and adolescents with Asperger syndrome. Journal of Child Psychology and Psychiatry 43, 517528.CrossRefGoogle ScholarPubMed
Kaufman, AS (1994). Intelligent Testing with the WISC-III. Wiley: New York.Google Scholar
Kay, SR, Fiszbein, A, Opler, LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261276.CrossRefGoogle ScholarPubMed
Lord, C, Rutter, M, LeCouteur, A (1994). Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders 24, 659685.CrossRefGoogle ScholarPubMed
Losh, M, Adolphs, A, Poe, MD, Couture, S, Penn, D, Baranek, GT, Piven, J (2009). Neuropsychological profile of autism and the broad autism phenotype. Archives of General Psychiatry 66, 518526.CrossRefGoogle ScholarPubMed
Loveland, KA, Tunali-Kotoski, B, Chen, YR, Ortegon, J, Pearson, DA, Brelsford, KA, Gibbs, MC (1997). Emotion recognition in autism: verbal and nonverbal information. Development and Psychopathology 9, 579593.CrossRefGoogle ScholarPubMed
Marx, J (2007). Evidence linking DISC1 gene to mental illness builds. Science 318, 10621063.CrossRefGoogle ScholarPubMed
Muris, P, Steerneman, P, Meesters, C, Merckelbach, H, Horselenberg, R, van den Hogen, T, van Dongen, L (1999). The TOM test: a new instrument for assessing theory of mind in normal children and children with pervasive developmental disorders. Journal of Autism and Developmental Disorders 29, 6780.CrossRefGoogle Scholar
Nettle, D, Liddle, B (2008). Agreeableness is related to social-cognitive, but not social-perceptual theory of mind. European Journal of Psychiatry 22, 323335.Google Scholar
Penn, DL, Combs, DR, Ritchie, M, Francis, J, Cassisi, J, Morris, S, Townsend, M (2000). Emotion recognition in schizophrenia: further investigation of generalized versus specific deficit models. Journal of Abnormal Psychology 109, 512516.CrossRefGoogle ScholarPubMed
Phillips, ML, Drevets, WC, Rauch, SL, Lane, RD (2003). Neurobiology of emotion perception. I: The neural basis of normal emotion perception. Biological Psychiatry 54, 504514.CrossRefGoogle ScholarPubMed
Pilowsky, T, Yirmiya, N, Arbelle, S, Mozes, T (2000). Theory of mind abilities of children with schizophrenia, children with autism, and normally developing children. Schizophrenia Research 42, 145155.CrossRefGoogle ScholarPubMed
Pinkham, AE, Hopfinger, JB, Pelphrey, KA, Piven, J, Penn, DL (2008). Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders. Schizophrenia Research 99, 164175.CrossRefGoogle ScholarPubMed
Rutherford, MD, Baron-Cohen, S, Wheelwright, S (2002). Reading the mind in the voice: a study with normal adults and adults with Asperger syndrome and high functioning autism. Journal of Autism and Developmental Disorders 32, 189194.CrossRefGoogle Scholar
Sabbagh, MA (2004). Recognizing and reasoning about mental states: understanding orbitofrontal contributions to theory of mind in autism. Brain and Cognition 55, 209219.CrossRefGoogle Scholar
Sasson, N, Tsuchiya, N, Hurley, R, Couture, S, Penn, DL, Adolphs, R, Piven, J (2007). Orienting to social stimuli differentiates social cognitive impairment in autism and schizophrenia. Neuropsychologia 45, 25802588.CrossRefGoogle ScholarPubMed
Sheitman, BB, Kraus, JE, Bodfish, JW, Carmel, H (2003). Are the negative symptoms of schizophrenia consistent with an autistic spectrum illness? Schizophrenia Research 69, 119120.CrossRefGoogle Scholar
Sprong, M, Schothorst, P, Vos, E, Hox, J, Engeland, HV (2007). Theory of mind in schizophrenia: meta-analysis. British Journal of Psychiatry 191, 5–13.CrossRefGoogle ScholarPubMed
Van Lancker, DR, Cornelius, C, Kreiman, J (1989). Recognition of emotional-prosodic meanings in speech by autistic, schizophrenic, and normal children. Developmental Neuropsychology 5, 207226.CrossRefGoogle Scholar
Winston, JS, Strange, BA, O'Doherty, J, Dolan, RJ (2002). Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nature Neuroscience 5, 277283.CrossRefGoogle ScholarPubMed
Wechsler, D (1999). Wechsler Abbreviated Scale of Intelligence (WASI) Manual. Psychological Corporation: San Antonio, TX.Google Scholar