Journal of the International Neuropsychological Society

Research Articles

Prospective memory function in mild cognitive impairment and early dementia

CLAIRE THOMPSONa1a2a3 c1, JULIE D. HENRYa1, PETER G. RENDELLa4, ADRIENNE WITHALLa2a3 and HENRY BRODATYa2a3

a1 School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia

a2 Primary Dementia Collaborative Research Centre, School of Psychiatry, University of New South Wales, Sydney 2052, Australia

a3 Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Sydney 2031, Australia

a4 School of Psychology, Australian Catholic University, Melbourne, Australia

Abstract

When compared with controls, both mild cognitive impairment (MCI) and dementia are each associated with impaired memory for future intentions, or prospective memory (PM). However, prior studies have failed to agree on whether there are group differences in PM function between those with MCI and dementia. Furthermore, the degree and nature of the impairment remains to be clarified, as does the degree to which this impairment is secondary to deficits in other aspects of cognition. In the present study, MCI (n = 48), dementia (n = 39), and control participants (n = 53) were compared on Virtual Week, a measure that closely represents the types of PM tasks that occur in everyday life. Both clinical groups exhibited impairment irrespective of the specific task demands, but the magnitude of this deficit was greater for those with dementia. After covarying for other key cognitive parameters, although the absolute magnitude of the deficit was reduced, significant impairment remained. These results indicate that individuals with MCI, and to a greater extent dementia, experience generalized difficulties with PM. It is suggested that, while other cognitive deficits contribute to these difficulties, there is something unique to prospective remembering that may be additionally disrupted in these groups. (JINS, 2010, 16, 318–325.)

(Received July 13 2009)

(Reviewed November 17 2009)

(Accepted November 18 2009)

Correspondence:

c1 Correspondence and reprint requests to: Claire Thompson, School of Psychology, University of New South Wales, Sydney, NSW, 2052, Australia. E-mail: cthompson@psy.unsw.edu.au