Journal of the International Neuropsychological Society

Research Articles

Characteristics of executive function impairment in Parkinson’s disease patients without dementia

AUDREY MCKINLAYa1 c1, RANDOLPH C. GRACEa1, JOHN C. DALRYMPLE-ALFORDa1 and DEREK ROGERa1

a1 Department of Psychology, University of Canterbury, Christchurch, New Zealand

Abstract

Executive function impairments in Parkinson’s disease (PD) are well documented. However, uncertainties remain regarding the impact of these deficits on other areas of cognitive functioning. The goal of this study was to provide a comprehensive assessment of cognitive characteristics in patients with PD without dementia and to assess how any such deficits affected other areas of cognitive functioning. Forty PD patients without dementia were compared to healthy controls using measures of attention and speed of processing and a comprehensive set of executive function tests including working memory, planning, and problem solving. Measures of memory/learning and visuospatial skills were also included to examine the relationship between aspects of executive function and other areas of cognition. Patients with PD showed deficits on measures of executive function, problem solving, and visuospatial skills. However, they were unimpaired on measures of planning, attention, and memory/learning. Deficits in problem solving were only evident for tasks with a high visuospatial content and were no longer significant when visuospatial skills were controlled for. While deficits in executive function and visuospatial skills were apparent for PD patients compared to controls, many aspects of cognition remained intact. These can provide a focus for cognitive intervention strategies that can be effective in delaying decline for PD patients. (JINS, 2010, 16, 268–277.)

(Received January 18 2009)

(Reviewed October 24 2009)

(Accepted October 25 2009)

Correspondence:

c1 Correspondence and reprint requests to: Audrey McKinlay, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. E-mail: audrey.mckinlay@canterbury.ac.nz

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