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Actinobacillus pleuropneumoniae surface polysaccharides: their role in diagnosis and immunogenicity

Published online by Cambridge University Press:  28 February 2007

J. Daniel Dubreuil ,
Mario Jacques ,
Khyali R. Mittal  and
Marcelo Gottschalk
J. Daniel Dubreuil*
Affiliation:
Groupe de recherche sur les maladies infectieuses du porc (GREMIP), Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte C.P. 5000, Saint-Hyacinthe, Québec, CanadaJ2S 7C6
Mario Jacques
Affiliation:
Groupe de recherche sur les maladies infectieuses du porc (GREMIP), Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte C.P. 5000, Saint-Hyacinthe, Québec, CanadaJ2S 7C6
Khyali R. Mittal
Affiliation:
Groupe de recherche sur les maladies infectieuses du porc (GREMIP), Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte C.P. 5000, Saint-Hyacinthe, Québec, CanadaJ2S 7C6
Marcelo Gottschalk
Affiliation:
Groupe de recherche sur les maladies infectieuses du porc (GREMIP), Faculté de médecine vétérinaire, Université de Montréal, 3200 Sicotte C.P. 5000, Saint-Hyacinthe, Québec, CanadaJ2S 7C6
*
*E-mail: daniel.dubreuil@umontreal.ca
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Abstract

Actinobacillus pleuropneumoniae is an important pig pathogen that is responsible for swine pleuropneumonia, a highly contagious respiratory infection. Knowledge of the importance, composition and structural determination of the major antigens involved in virulence provides crucial information that could lead to the development of a rationale for the production of specific serodiagnostic tools as well as vaccine development. Thus, efforts have been devoted to study mainly A. pleuropneumoniaevirulence determinants with special emphasis on the Apx toxins (for A. pleuropneumoniaeRTX toxins). In comparison, little attention has been given to the surface polysaccharides, which include capsular polysaccharides (CPS) and cell-wall lipopolysaccharides (LPS). Here, we review current knowledge on CPS and LPS of A. pleuropneumoniae used as diagnostic tools to monitor the infection and as immunogens for inclusion in vaccine preparations for animal protection.

Type
Research Article
Information
Animal Health Research Reviews , Volume 1 , Issue 2 , December 2000 , pp. 73 - 93
Copyright
Copyright © CAB International 2000

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