Epidemiology and Infection

Table of Contents - 2010 - Volume 138, Issue 03  

Cambridge Journals Online - CUP Full-Text Page
Epidemiology and Infection (2010), 138:442-447 Cambridge University Press
Copyright © Cambridge University Press 2009
doi:10.1017/S0950268809990732

Original Papers

Childhood infections

Anti-VP6 IgG antibodies against group A and group C rotaviruses in South India

I. MUKHOPADHYAa1, D. ANBUa1, M. ITURRIZA-GOMARAa2, J. J. GRAYa2, D. W. BROWNa2, O. KAVANAGHa3, M. K. ESTESa3 and G. KANGa1 c1

a1 Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India
a2 Virus Reference Department, Centre for Infection, Health Protection Agency, London, UK
a3 Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
Article author query
mukhopadhya i [PubMed]  [Google Scholar]
anbu d [PubMed]  [Google Scholar]
iturriza-gomara m [PubMed]  [Google Scholar]
gray jj [PubMed]  [Google Scholar]
brown dw [PubMed]  [Google Scholar]
kavanagh o [PubMed]  [Google Scholar]
estes mk [PubMed]  [Google Scholar]
kang g [PubMed]  [Google Scholar]

SUMMARY

In an epidemiological survey from South India, 936 serum samples were tested for IgG against recombinant baculovirus-expressed VP6 proteins from human group A and group C rotaviruses. The overall seroprevalence for group A was 100% and for group C was 25·32% (95% CI 22·64–28·21). The lowest seroprevalence for group C was in children aged <10 years (16·79%). An age-related rise in seroprevalence in group C, but not group A, suggests different patterns of exposure. Seroprevalence was similar in rural and urban subjects, unlike the higher prevalence in rural subjects in studies elsewhere.

(Accepted August 12 2009)

(Online publication September 02 2009)

Key Words:Gastrointestinal infections; infectious disease epidemiology; rotavirus; serology

Correspondence:

c1 Author for correspondence: Dr G. Kang, Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India. (Email: gkang@cmcvellore.ac.in)

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