Journal of the International Neuropsychological Society

Research Articles

Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder

ALESSANDRA M. PASSAROTTIa1a2 c1, JOHN A. SWEENEYa1a3 and MANI N. PAVULURIa1a2

a1 Center for Cognitive Medicine, University of Illinois Medical Center at Chicago, Chicago, IL

a2 Institute for Juvenile Research, University of Illinois Medical Center at Chicago, Chicago, IL

a3 Department of Bioengineering, University of Illinois Medical Center at Chicago, Chicago, IL

Abstract

This fMRI study investigates the neural bases of cognitive control of emotion processing in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). Seventeen un-medicated PBD patients, 15 un-medicated ADHD patients, and 14 healthy controls (HC) (mean age = 13.78 ± 2.47) performed an emotional valence Stroop Task, requiring them to match the color of an emotionally valenced word to the color of either of two adjacent circles. Both patient groups responded significantly slower than HC, but there were no group differences in accuracy. A voxel-wise analysis of variance on brain activation revealed a significant interaction of group by word valence [F(2,41) = 4.44; p = .02]. Similar group differences were found for negative and positive words. For negative versus neutral words, both patient groups exhibited greater activation in dorsolateral prefrontal cortex (DLPFC) and parietal cortex relative to HC. The PBD group exhibited greater activation in ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) relative to HC. The ADHD group exhibited decreased VLPFC activation relative to HC and the PBD group. During cognitive control of emotion processing, PBD patients deployed the VLPFC to a greater extent than HC. The ADHD patients showed decreased VLPFC engagement relative to both HC and PBD patients. (JINS, 2010, 16, 106–117.)

(Received March 25 2009)

(Reviewed September 14 2009)

(Accepted September 15 2009)

Correspondence:

c1 Correspondence and reprint requests to: Alessandra M. Passarotti, Institute for Juvenile Research and Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street (M/C 913), Chicago, IL 60612. E-mail: apassarotti@psych.uic.edu

Footnotes

Dr. Passarotti has no financial relationships to disclose. Dr. Pavuluri’s work unrelated to this manuscript is supported by NARSAD Independent Investigator Award, NICHD, GlaxoSmithKline-NeuroHealth, Abbott Pharmaceuticals, and Janssen Research Foundation. Dr. Sweeney, also unrelated to this work, has received support from NIH, GlaxoSmithKline, AstraZeneca, Janssen and Eli Lilly.

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