Behavioral and Brain Sciences

Authors' Responses

Grafts and the art of mind's reconstruction

John D. Sindena1, Helen Hodgesa1 and Jeffrey A. Graya1

a1 Department of Psychology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 BAF, England,


The use of neural transplantation to alleviate cognitive deficits is still in its infancy. We have an inadequate understanding of the deficits induced by different types of brain damage and their homologies in animal models against which to assess graft-induced recovery, and of the ways in which graft growth and function are influenced by factors within the host brain and the environment in which the host is operating. Further, use of fetal tissue may only be a transitory phase in the search for appropriate donor sources. Nevertheless, findings from our laboratory and elsewhere have made a prima facie case for successful cognitive reconstruction by graft methods.