Behavioral and Brain Sciences

Open Peer Commentary

Pathway rewiring with neural transplantation

Piergiorgio Strataa1 and Ferdinando Rossia1

a1 Department of Anatomy and Human Physiology, University of Turin, 10125 Turin, Italy.


A lesion to the brain is not necessary for a successful neural transplantation. Embryonic Purkinje cells placed on the surface of an uninjured adult cerebellum can develop and migrate into the host molecular layer. Both the Purkinje cells that migrated into the host cerebellum and those that remained in the graft were innervated by collateral sprouting of adult intact climbing fibers.