Behavioral and Brain Sciences

Open Peer Commentary

Neural grafting in human disease versus animal models: Cautionary notes

Kathy Steece-Colliera1

a1 Department of Neurology, University of Rochester School of Medicine, Rochester, NY 14619


Over the past two decades, research on neural transplantation in animal models of neurodegeneration has provided provocative in sights into the therapeutic use of grafted tissue for various neurological diseases. Although great strides have been made and functional benefits gained in these animal models, much information is still needed with regard to transplantation in human patients. Several factors are unique to human disease, for example, age of the recipient, duration of disease, and drug interaction with grafted cells; these need to be explored before grafting can be considered a safe and effective therapeutic tool.