Behavioral and Brain Sciences

Open Peer Commentary

Studying restoration of brain function with fetal tissue grafts: Optimal models

Rae Silvera1 and Joseph LeSautera1

a1 Barnard College of Columbia University, New York, NY 10027.


We concur that basic research on the use of CNS grafts is needed. Two important model systems for functional studies of grafts are ignored by Stein & Glasier. In the first, reproductive function is restored in hypogonadal mice by transplantation of GnRH-synthesizing neurons. In the second, circadian rhythmicity is restored by transplantation of the suprachiasmatic nucleus.