Behavioral and Brain Sciences

Open Peer Commentary

Studying restoration of brain function with fetal tissue grafts: Optimal models

Rae Silvera1 and Joseph LeSautera1

a1 Barnard College of Columbia University, New York, NY 10027. qr@columbia.edu

Abstract

We concur that basic research on the use of CNS grafts is needed. Two important model systems for functional studies of grafts are ignored by Stein & Glasier. In the first, reproductive function is restored in hypogonadal mice by transplantation of GnRH-synthesizing neurons. In the second, circadian rhythmicity is restored by transplantation of the suprachiasmatic nucleus.

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