Behavioral and Brain Sciences

Open Peer Commentary

Lessons on transplant survival from a successful model system

Stacia B. Moffetta1

a1 Department of Zoology, Washington State University, Pullman, WA 99164-4236.


Studies on the snail Melampus reveal that connectivity is crucial to the survival of transplanted ganglia. Transplanted CNS ganglia can innervate targets or induce supernumerary structures. Neuron survival is optimized by the neural incorporation that occurs when a transplanted ganglion is substituted for an excised ganglion. Better provision for the trophic requirements of neurons will improve the success of mammalian fetal transplants.