Behavioral and Brain Sciences

Open Peer Commentary

Intraretrosplenial grafts of cholinergic neurons and spatial memory function

Ying J. Lia1 and Walter C. Lowa1a2a3

a1 Departments of Neurosurgery

a2 Departments of Physiology

a3 Departments of Program in Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455.


The transplantation of cholinergic neurons into the hippocampal formation has been well characterized. We describe our studies on the effects of cholinergic transplants in the retrosplenial cortex. These transplants were capable of ameliorating spatial navigation deficits in rats with septohippocampal lesions. In addition, we provide evidence for the modulation of transplanted neurons by the host brain.