a1 Departments of Neurosurgery
a2 Departments of Physiology
a3 Departments of Program in Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455. email@example.com
The transplantation of cholinergic neurons into the hippocampal formation has been well characterized. We describe our studies on the effects of cholinergic transplants in the retrosplenial cortex. These transplants were capable of ameliorating spatial navigation deficits in rats with septohippocampal lesions. In addition, we provide evidence for the modulation of transplanted neurons by the host brain.