Behavioral and Brain Sciences

Open Peer Commentary

Elegant studies of transplant-derived repair of cognitive performance

Stephen B. Dunnetta1 and Eduardo M. Torresa1

a1 MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom,


Cholinergic-rich grafts have been shown to be effective in restoring maze-learning deficits in rats with lesions of the forebrain cholinergic projection system. However, the relevance of those studies to developing novel therapies for Alzheimer's disease is questioned.