Behavioral and Brain Sciences

Open Peer Commentary

Multiple potential mechanisms of graft action is not a new idea

Stephen B. Dunnetta1

a1 MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom.


It is well established that neural grafts can exert functional effects on the host animal by a multiplicity of different mechanisms – by diffuse release of trophic molecules, neurohormones, and deficient neurotransmitters, as well as by growth and reformation of neural circuits. Our challenge is to understand how these different mechanisms complement each other.