Behavioral and Brain Sciences

Open Peer Commentary

The structure, operation, and functionality of intracerebral grafts

Jean-Christophe Cassela1 and Bruno Willa1

a1 Laboratoire de Neurophysiologie et Biologie des Comportements, Unité Propre de Recherche 419 du CNRS, Centre de Neurochimie-Université Louis Pasteur, F-67000 Strasbourg, France


The concept of structure, operation, and functionality, as they may be understood by clinicians or researchers using neural transplantation techniques, are briefly defined. Following Stein & Glasier, we emphasize that the question of whether an intracerebral graft is really functional should be addressed not only in terms of what such a graft does in a given brain structure, but also in terms of what it does at the level of the organism.