Behavioral and Brain Sciences

Open Peer Commentary

Neural transplants are grey matters

Britt Andersona1, Anjan Chatterjeea1 and George Grahama2

a1 Department of Neurology, University of Alabama School of Medicine, Birmingham, AL 35294;

a2 Philosophy Department, University of Alabama at Birmingham, Birmingham, AL 35294. arhu006@uab.dpo


The lesion and transplantation data cited by Sinden et al., when considered in tandem, seem to harbor an internal inconsistency, raising questions of false localization of function. The extrapolation of such data to cognitive impairment and potential treatment strategies in Alzheimer's disease is problematic. Patients with focal basal forebrain lesions (e.g., anterior communicating artery aneurysm rupture) might be a more appropriate target population.