The International Journal of Neuropsychopharmacology

Table of Contents - 2007 - Volume 10, Issue 01  


Letter Paper

Amisulpride-induced hyperprolactinaemia is not reversed by addition of aripiprazole

Michael Paulzen a1c1 and Gerhard Gründer a1
a1 Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany

Article author query
paulzen m   [PubMed][Google Scholar] 
grunder g   [PubMed][Google Scholar] 

Hyperprolactinaemia is a well-recognized neuroendocrine response to antipsychotics (Gründer et al., 1999). Both typical and ‘atypical’ antipsychotics have the potential to elevate serum prolactin levels due to their dopamine D2 receptor antagonism (Turrone et al., 2002) ‘Atypical’ antipsychotics with higher dopamine D2 receptor affinities such as risperidone (David et al., 2000) are associated with more pronounced elevation of serum prolactin than those with intermediate or lower affinity such as olanzapine, clozapine, and quetiapine (David et al., 2000). Substituted benzamide antipsychotics such as amisulpride belong to the class of drugs with the strongest potency for prolactin elevation. On the other hand, the partial agonist antipsychotic, aripiprazole, has been shown to lower serum prolactin below placebo levels when it is used as a single agent (Keck et al., 2003).

(Received June 18 2006)
(Accepted June 25 2006)
(Published Online August 31 2006)


Correspondence:
c1 Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany. Tel.: +49-241-80-89643 Fax: +49-241-80-82401 E-mail: mpaulzen@ukaachen.de

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