Journal of the International Neuropsychological Society

Brief Communications

A large-scale retrospective study of closing-in behavior in Alzheimer’s disease

ELISABETTA AMBRONa1a2, ROBERT D. MCINTOSHa1 c1, FRANCESCA ALLARIAa3 and SERGIO DELLA SALAa1a4

a1 Department of Psychology, Human Cognitive Neuroscience, University of Edinburgh, Edinburgh, United Kingdom

a2 Laboratory of Experimental Psychology, Suor Orsola Benincasa University, Naples, Italy

a3 Third Neurological Department, University of Milan, St. Paolo Hospital, Milan, Italy

a4 Department of Psychology, Center for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom

Abstract

The frequency and characteristics of closing-in behavior (CIB) were examined in 797 patients with Alzheimer’s disease (AD), 132 of whom were followed up longitudinally. The frequency of CIB increased with the complexity of the graphic copying task and with the severity of Alzheimer’s disease. Regression analyses suggested that attentional deficits are critical factors for the appearance of CIB, but that visuospatial impairments also play an important role in the emergence of severe forms of CIB. (JINS, 2009, 15, 787–792.)

(Received February 04 2009)

(Reviewed May 11 2009)

(Accepted May 14 2009)

Correspondence:

c1 Correspondence and reprint requests to: Robert D. McIntosh, Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ. E-mail: r.d.mcintosh@ed.ac.uk