Journal of Helminthology

Research Note

Schistosoma mansoni: the survival and reproductive status of mature infections in mice treated with oxamniquine

Irene Popiela1 p1 and David A. Erasmusa1

a1 Department of Zoology, University College, Cardiff, Wales, UK

Abstract

A single oral dose of 50 mg/kg of oxamniquine administered to mice with mature infections of Schistosoma mansoni gave rise to a hepatic shift and almost total elimination of the male worms. Regression of the reproductive system and a conspicuous reduction in size took place in the residual females which eventually resembled sexually immature adults. A second dose of oxamniquine had no apparent effect on these females within a period of 28 days following this treatment and it is suggested that this change in reproductive status is the result of discontinued male stimulation.

(Accepted December 03 1981)

Correspondence:

p1 Present address: Department of Tropical Pathology, The South African Institute for Medical Research, Hospital Street, Johannesburg 2000, South Africa