a1 Department of Zoology, University College, Cardiff, Wales, UK
A single oral dose of 50 mg/kg of oxamniquine administered to mice with mature infections of Schistosoma mansoni gave rise to a hepatic shift and almost total elimination of the male worms. Regression of the reproductive system and a conspicuous reduction in size took place in the residual females which eventually resembled sexually immature adults. A second dose of oxamniquine had no apparent effect on these females within a period of 28 days following this treatment and it is suggested that this change in reproductive status is the result of discontinued male stimulation.
(Accepted December 03 1981)
p1 Present address: Department of Tropical Pathology, The South African Institute for Medical Research, Hospital Street, Johannesburg 2000, South Africa