Amphotericin B nasal spray has no effect on nasal polyps
Nasal polyps and chronic rhinosinusitis are the products of an inflammatory process. Recently, fungal involvement has been thought to stimulate the development of polyps, and administration of antifungal agents was therefore considered a potential treatment. Several studies have been published indicating amphotericin B as an effective treatment for nasal polyps and chronic rhinosinusitis. The aim of our investigation was to evaluate the efficacy of intranasal applied amphotericin B on the growth of nasal polyps in a three-month, prospective, open trial. Our results show that nasal amphotericin B spray is not effective for nasal polyps and may even cause deterioration.(Published Online September 11 2006)
(Accepted March 2 2006)
Key Words: Nasal Polyps; Amphotericin B; Antifungal Agents.
c1 Address for correspondence: Dr Marco Caversaccio, Department of ENT and Head and Neck Surgery, University Hospital (Inselspital), CH-3010 Bern, Switzerland. Fax: +41 31 632 49 00 E-mail: [email protected]