The Journal of Laryngology & Otology



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Amphotericin B nasal spray has no effect on nasal polyps


Helbling a1 , Baumann a2 , Hänni a3 and Caversaccio a2c1
a1 Division of Allergology, Department of Rheumatology and Clinical Immunology/Allergology, University Hospital (Inselspital), Bern, Switzerland
a2 Department of ENT and Head and Neck Surgery, Institute of Pharmacy, University Hospital (Inselspital), Bern, Switzerland
a3 Department of Oncology, Institute of Pharmacy, University Hospital (Inselspital), Bern, Switzerland

Article author query
helbling a   [PubMed][Google Scholar] 
baumann a   [PubMed][Google Scholar] 
hänni c   [PubMed][Google Scholar] 
caversaccio m   [PubMed][Google Scholar] 

Abstract

Nasal polyps and chronic rhinosinusitis are the products of an inflammatory process. Recently, fungal involvement has been thought to stimulate the development of polyps, and administration of antifungal agents was therefore considered a potential treatment. Several studies have been published indicating amphotericin B as an effective treatment for nasal polyps and chronic rhinosinusitis. The aim of our investigation was to evaluate the efficacy of intranasal applied amphotericin B on the growth of nasal polyps in a three-month, prospective, open trial. Our results show that nasal amphotericin B spray is not effective for nasal polyps and may even cause deterioration.

(Published Online September 11 2006)
(Accepted March 2 2006)


Key Words: Nasal Polyps; Amphotericin B; Antifungal Agents.

Correspondence:
c1 Address for correspondence: Dr Marco Caversaccio, Department of ENT and Head and Neck Surgery, University Hospital (Inselspital), CH-3010 Bern, Switzerland. Fax: +41 31 632 49 00 E-mail: marco.caversaccio@insel.ch