Neuropsychological profiles of patients with obsessive-compulsive disorder: early onset versus late onset
In this study, we assess the neuropsychological profiles of both early and late symptom-onset obsessive-compulsive disorder (OCD) patients. The early and late-onset OCD patients are compared to the control group with a series of neuropsychological measurements. The late-onset OCD patients exhibited impaired performance on the immediate and the delayed recall conditions of the Rey-Osterrieth Complex Figure Test (RCFT) and the letter and category fluency of the Controlled Oral Word Association Test (COWA), compared to the normal controls and the early-onset OCD patients. The controls and early-onset OCD patients did not differ on any of the neuropsychological measurements taken in this study. These results suggest that different neurophysiological mechanisms are in play in early and late-onset OCD patients, and age of onset can serve as a potential marker for the subtyping of OCD. (JINS, 2007, 13, 30–37.)(Received January 11 2006)
(Revised August 15 2006)
(Accepted August 16 2006)
Key Words: Obsessive-compulsive disorder (OCD); Subtype; Age of onset; Neuropsychological functions; Early-onset OCD; Late-onset OCD.
c1 Correspondence and reprint requests to: Dr. Jun Soo Kwon, Professor, Department of Psychiatry, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, Korea 110-744. E-mail: [email protected]